5α-Dihydrocortisol (5α-DHF), a metabolite of Hydrocortisone (Cortisol), is a steroid hormone. 5α-Dihydrocortisol can enhance the mineralocorticoid activity of aldosterone [1] [2].
In Vitro, In the adrenalectomized rat kidney, in vitro, 5α-Dihydrocortisol (5α-DHF) has 20% the affinity of Dexamethasone for classical (type II) glucocorticoid receptors, 10% the affinity of Corticosterone for (type III) corticosteroid-binding globulin-like glucocorticoid receptors, and 3% the affinity of Aldosterone for mineralocorticoid receptors (type I). 5α-Dihydrocortisol has <0.1% the affinity of Dihydrotestosterone in mouse kidney receptors and <0.1% the affinity of both Estradiol and Progesterone for their receptors in rat uterus[1].
References:
[1]. Adam WR, et al. Amplification of the action of aldosterone by 5 alpha-dihydrocortisol. Endocrinology. 1978 Aug;103(2):465-71.
[2]. Mikami H, et al. The effect of 5 alpha-dihydrocortisol on the blood pressure of rats treated with deoxycorticosterone acetate and salt. Endocrinol Jpn. 1980 Dec;27(6):769-73.
In Vitro, In the adrenalectomized rat kidney, in vitro, 5α-Dihydrocortisol (5α-DHF) has 20% the affinity of Dexamethasone for classical (type II) glucocorticoid receptors, 10% the affinity of Corticosterone for (type III) corticosteroid-binding globulin-like glucocorticoid receptors, and 3% the affinity of Aldosterone for mineralocorticoid receptors (type I). 5α-Dihydrocortisol has <0.1% the affinity of Dihydrotestosterone in mouse kidney receptors and <0.1% the affinity of both Estradiol and Progesterone for their receptors in rat uterus[1].
References:
[1]. Adam WR, et al. Amplification of the action of aldosterone by 5 alpha-dihydrocortisol. Endocrinology. 1978 Aug;103(2):465-71.
[2]. Mikami H, et al. The effect of 5 alpha-dihydrocortisol on the blood pressure of rats treated with deoxycorticosterone acetate and salt. Endocrinol Jpn. 1980 Dec;27(6):769-73.