Bactofencin A acetate is a class IId bacteriocin and Antibacterial agent. Bactofencin A acetate is produced by Lactobacillus salivarius DPC6502, an isolate derived from the intestine. Bactofencin A acetate exhibits activity against Staphylococcus and Listeria species. Bactofencin A acetate slightly modulates the intestinal flora. Bactofencin A acetate can be used in research related to staphylococcal infections, listerial infections, and mastitis [1].
In Vitro, Bactofencin A (0.25-1000 µM; assay duration at 37 °C) acetate exhibit potent anti-Staphylococcus aureus DPC5246 activity[1]. Bactofencin A (0.25-1000 µM; assay duration at 37 °C) acetate with substitution of Cys7 or Cys22 with serine or alanine significantly reduces anti-Staphylococcus aureus DPC5246 activity, with C22 substitutions causing greater activity loss than C7 substitutions[1].
References:
[1]. O' Connor PM, et al. The potency of the broad spectrum bacteriocin, bactofencin A, against staphylococci is highly dependent on primary structure, N-terminal charge and disulphide formation. Sci Rep. 2018;8(1):11833. Published 2018 Aug 7.
In Vitro, Bactofencin A (0.25-1000 µM; assay duration at 37 °C) acetate exhibit potent anti-Staphylococcus aureus DPC5246 activity[1]. Bactofencin A (0.25-1000 µM; assay duration at 37 °C) acetate with substitution of Cys7 or Cys22 with serine or alanine significantly reduces anti-Staphylococcus aureus DPC5246 activity, with C22 substitutions causing greater activity loss than C7 substitutions[1].
References:
[1]. O' Connor PM, et al. The potency of the broad spectrum bacteriocin, bactofencin A, against staphylococci is highly dependent on primary structure, N-terminal charge and disulphide formation. Sci Rep. 2018;8(1):11833. Published 2018 Aug 7.