Bifenthrin (Synonyms: (±)-Bifenthrin) |
Catalog No.GC60642
One-Click Copy Product Info
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Bifenthrin es un insecticida piretroide. Su principal diana en la acción neurotóxica es el canal de sodio voltaje-dependiente de la membrana neuronal
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 82657-04-3
Sample solution is provided at 25 µL, 10mM.
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Bifenthrin es un insecticida piretroide. Su principal diana en la acción neurotóxica es el canal de sodio voltaje-dependiente de la membrana neuronal [1]. Presenta mayor fotoestabilidad y actividad insecticida, pero resulta neurotóxico para diversos animales. Los signos clínicos de su toxicicdad incluen temblores y convulsiones[1, 2].
Bifenthrin (20μM; 24h) provocó un aumento notable de la producción de PGE2, óxido nítrico NO y TNF-a en microglías primarias. También elevó la expresión del mRNA de IL-6 y TNF-a en dichas células[3]. Bifenthrin (1, 1.5μM; 24h) redujo la actividad de la glutación peróxido en eritrocitos. A una concentración de (1.5μM; 24h), indujo hemólisis eritrocitaria[2].
Bifenthrin (30, 60ng/L; 14d) incrementó el número de vasos sanguíneos congestionados en ejemplares juveniles de trucha arcoíris[4]. Bifenthrin (8mg/kg; 7d; i.p.) causó pincnosis nuclear localizada y degenración vacular en el hígado de algunos ratones BALB/c. Una dosis de 2, 4, 8mg/kg; 7d; i.p.), provocó un aumento dependiente de la concentración en la generación de ROS mitocondriales en estos ratones [5]. Bifenthrin (0.6mg/kg; 6 semanas; qod.; i.g.) aumentó el peso corporal de ratones C57BL/6. Asimismo, redujo la expresión de HSL y ATGL, mientras que incrementó de forma notable la expresión de LPL en estos animales[6].
References:
[1] Moreira C V L, Ogbu J s, Monteiro K L C, et al. Bifenthrin under scrutiny: revisiting toxicological evidence amid regulatory gaps [J]. Journal of applied toxicology : JAT, 2026, 46(1): 61-77.
[2] Mukhtar F, Jilani K, Bibi I, et al. Stimulation of erythrocyte membrane blebbing by Bifenthrin induced oxidative stress [J]. Dose-response : a publication of International Hormesis Society, 2022, 20(1): 15593258221076710.
[3] Gargouri B, Yousif N M, Bouchard M, et al. Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures [J]. Journal of neuroinflammation, 2018, 15(1): 159.
[4] Magnuson J T, Caceres L, Sy N, et al. The use of non-targeted lipidomics and histopathology to characterize the neurotoxicity of Bifenthrin to juvenile rainbow trout (Oncorhynchus mykiss) [J]. Environmental science & technology, 2022, 56(16): 11482-11492.
[5] Zhang Y, Lu M, Zhou P, et al. Multilevel evaluations of potential liver injury of bifenthrin [J]. Pesticide biochemistry and physiology, 2015, 122: 29-37.
[6] Wei C, Wang X, Yao X, et al. Bifenthrin induces fat deposition by improving fatty acid uptake and inhibiting lipolysis in mice [J]. Journal of agricultural and food chemistry, 2019, 67(51): 14048-14055.
| Experimentos celulares [1]: | |
Líneas celulares | Microglía primaria de ratas Sprague Dawley |
Método de preparación | Las células micreogliales estuvieron expuestas a Bifenthrin (DMSO como control) durante 24h. La expresión génica de TNF-alpha e IL-6 se analizó medinate PCR cuantitativa en tiempo real. |
Condiciones de reacción | 20μM; 24h |
Áreas de aplicación | Bifenthrin aumentó la expresión del mRNA de IL-6 y TNF-alpha en la microglía primaria. |
| Experimentos con animales [2]: | |
Modelos animales | Ratones BALB/c |
Método de preparación | Los animales fueron expuestas a la Bifenthrin a través de una inyección intraperitoneal de 0.3 mL de la concentración adecuada en aceite de maíz. Después de un período de tratamiewnto de 7 días, se recogieron los hígados para su análisis. |
Forma de dosificación | 2, 4, 8mg/kg; 7d; i.p. |
Áreas de aplicación | Bifenthrin resultó en un aumento dependiente de la concentración en la generación de ROS mitocondriales. |
References: | |
| Cas No. | 82657-04-3 | SDF | |
| Sinónimos | (±)-Bifenthrin | ||
| Canonical SMILES | O=C([C@H]1C(C)(C)[C@H]1/C=C(Cl)/C(F)(F)F)OCC2=C(C)C(C3=CC=CC=C3)=CC=C2 | ||
| Formula | C23H22ClF3O2 | M.Wt | 422.87 |
| Solubility | DMSO: 100 mg/mL (236.48 mM) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3648 mL | 11.824 mL | 23.6479 mL |
| 5 mM | 473 μL | 2.3648 mL | 4.7296 mL |
| 10 mM | 236.5 μL | 1.1824 mL | 2.3648 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)