Bone Growth & Remodeling

β-estradiol - d3 (β-β-estradiol - d3) es el estradiol marcado con deuterio.

ethyl 2,5-Dihydroxybenzoate is a dual modulator of bone cell differentiation.

Cathepsin L Inhibitor (Z-FY-CHO) es un compuesto que puede inhibir específicamente la actividad de la Cathepsin L (Ki = 0.185nM) y se utiliza para estudiar el papel de la Cathepsin L en la función lisosómica y la degradación de proteínas dentro de las células

BLU-782 es una terapia de precisión oral diseñada específicamente para atacar selectivamente el mutante ALK2.

DCC-3014 (DCC-3014) es un inhibidor dual de c-FMS (CSF-IR) y c-Kit extra&Iacute;do de la patente WO2014145025A2, Ejemplo de compuesto 10, tiene IC50 de <0.01 μM y 0.1-1 μM, respectivamente .

Vitamin D3-d7 is intended for use as an internal standard for the quantification of vitamin D3 by GC- or LC-MS.

17β-hydroxy Exemestane is the primary active metabolite of exemestane.

11β-Prostaglandina E2 (11β-Dinoprostona), un derivado de prostanoide, inhibe la uni&Oacute;n de [3H]PGE2 a las membranas hipotal&Aacute;micas en la rata con una Ki de 53,3 nM.

El &Aacute;cido alizarina-3-metiliminodiac&eacute;tico es un marcador de calcio y un agente quelante.

A potential impurity found in commercial preparations of aceclofenac

A potential impurity in commercial preparations of aceclofenac

Ac-VDVAD-CHO is an inhibitor of caspase-2, -3, and -7 (Kis = 3.5, 1, and 7.5 nM, respectively).

Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S.

Calcitonin is a peptide hormone that lowers blood calcium levels and inhibits bone resorption.

Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption.

Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM).

DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR).

KMN-80, un derivado de PGE1, es un agonista selectivo y potente del receptor EP4 con una CI50 y una Ki de 3 nM y 2,35 nM, respectivamente.

Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells).

Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone.

Parathyroid hormone (PTH) (1-34) is an N-terminal fragment of PTH that regulates bone remodeling.

Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4.

TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.

La peonidina 3-O-glucósido (cloruro), una antocianina, actúa como secretagogo de insulina.