Cholesteryl oleate is one of the most abundant lipids in the atherosclerotic plaque, which is associated with the progression of atherosclerosis [1]. Cholesteryl oleate can penetrate into the clusters composed of oleic acid dimers and decrease the rotational movements of oleic acid [2]. Cholesteryl oleate is widely used as an arterial atherosclerosis lesion model to verify the removal effect of 5.75μm free electron laser irradiation [3]. Cholesteryl oleate accumulates in prostate cancer and is significantly correlated with cancer progression, is employed as the diagnostic biomarker for prostate cancer[4]. Cholesteryl oleate has been widely used in low-toxicity cationic solid lipid nanoparticles to achieve safe and effective non-viral nucleic acid delivery[5].
References:
[1] Lee E S, Shon H K, Lee T G, et al. The regional ratio of cholesteryl palmitate to cholesteryl oleate measured by ToF-SIMS as a key parameter of atherosclerosis[J]. Atherosclerosis, 2013, 226(2): 378-384.
[2] Iwahashi M, Umehara A, Wakisaka K, et al. Effect of cholesterol and other additives on viscosity, self-diffusion coefficient, and intramolecular movements of oleic acid[J]. The Journal of Physical Chemistry B, 2007, 111(4): 740-747.
[3] Awazu K, Fukami Y. Selective removal of cholesteryl oleate through collagen films by MIR FEL[J]. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2001, 475(1-3): 650-655.
[4] Li J, Ren S, Piao H, et al. Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer[J]. Scientific reports, 2016, 6(1): 20984.
[5] Suñé-Pou M, Prieto-Sánchez S, El Yousfi Y, et al. Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy[J]. International journal of nanomedicine, 2018: 3223-3233.