Cholesteryl oleate (Synonyms: CE(18:1), 18:1(9Z) CE, 18:1(9Z) Cholesterol ester, NSC 18186) |
Catalog No.GC30278
One-Click Copy Product Info
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El oleato de colesterol es una forma esterificada de colesterol.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 303-43-5
Sample solution is provided at 25 µL, 10mM.
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Cholesteryl oleate is one of the most abundant lipids in the atherosclerotic plaque, which is associated with the progression of atherosclerosis [1]. Cholesteryl oleate can penetrate into the clusters composed of oleic acid dimers and decrease the rotational movements of oleic acid [2]. Cholesteryl oleate is widely used as an arterial atherosclerosis lesion model to verify the removal effect of 5.75μm free electron laser irradiation [3]. Cholesteryl oleate accumulates in prostate cancer and is significantly correlated with cancer progression, is employed as the diagnostic biomarker for prostate cancer[4]. Cholesteryl oleate has been widely used in low-toxicity cationic solid lipid nanoparticles to achieve safe and effective non-viral nucleic acid delivery[5].
References:
[1] Lee E S, Shon H K, Lee T G, et al. The regional ratio of cholesteryl palmitate to cholesteryl oleate measured by ToF-SIMS as a key parameter of atherosclerosis[J]. Atherosclerosis, 2013, 226(2): 378-384.
[2] Iwahashi M, Umehara A, Wakisaka K, et al. Effect of cholesterol and other additives on viscosity, self-diffusion coefficient, and intramolecular movements of oleic acid[J]. The Journal of Physical Chemistry B, 2007, 111(4): 740-747.
[3] Awazu K, Fukami Y. Selective removal of cholesteryl oleate through collagen films by MIR FEL[J]. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2001, 475(1-3): 650-655.
[4] Li J, Ren S, Piao H, et al. Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer[J]. Scientific reports, 2016, 6(1): 20984.
[5] Suñé-Pou M, Prieto-Sánchez S, El Yousfi Y, et al. Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy[J]. International journal of nanomedicine, 2018: 3223-3233.
| Cas No. | 303-43-5 | SDF | |
| Sinónimos | CE(18:1), 18:1(9Z) CE, 18:1(9Z) Cholesterol ester, NSC 18186 | ||
| Canonical SMILES | CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C | ||
| Formula | C45H78O2 | M.Wt | 651.1 |
| Solubility | DMS : 5.2 mg/mL (7.99 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5359 mL | 7.6793 mL | 15.3586 mL |
| 5 mM | 307.2 μL | 1.5359 mL | 3.0717 mL |
| 10 mM | 153.6 μL | 767.9 μL | 1.5359 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)