DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC50 of 0.0092 μM at 14 μM NAD and an IC50 of 0.069 μM at 250 μM NAD. DHPS-IN-3 is applicable for cancer research [1].
In Vitro, DHPS-IN-3 potently inhibits deoxyhypusine synthase with an IC50 of 0.0092 μM at 14 μM NAD, showing a NAD-competitive inhibitory profile[1].
References:
[1]. Tanaka Y, et al. New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. ACS Med Chem Lett. 2020;11(8):1645-1652. Published 2020 Jul 30.
In Vitro, DHPS-IN-3 potently inhibits deoxyhypusine synthase with an IC50 of 0.0092 μM at 14 μM NAD, showing a NAD-competitive inhibitory profile[1].
References:
[1]. Tanaka Y, et al. New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. ACS Med Chem Lett. 2020;11(8):1645-1652. Published 2020 Jul 30.