GLPBio

EZH2

EZH2 (enhancer of zeste homolog 2) is a polycomb group protein and histone methyltrasferase that associated with transcriptional repression. It catalyzes trimethylation of H3K27me3 (histone H3 lysine 27) as a catalytic subunit of PRC2 (polycomb repressive complex 2).

Products Related to EZH2(10)

  • GC11414 structure
    GC11414GSK503
    CAS: 1346572-63-1
    Purity: >99.50%

    GSK503 es un inhibidor potente y especÍfico de la metiltransferasa EZH2 con valores de Kiapp de 3 a 27 nM.

  • GC13145 structure
    GC131453-Deazaneplanocin,DZNep
    CAS: 102052-95-9
    Purity: >98.00%

    An inhibitor of lysine methyltransferase EZH2

  • GC13878 structure
    GC13878EPZ005687
    CAS: 1396772-26-1
    Purity: >99.00%

    A potent, selective inhibitor of EZH2

  • GC15783 structure
    GC15783GSK126
    CAS: 1346574-57-9
    Purity: >98.00%

    GSK126 (GSK2816126A, GSK2816126) es un inhibidor de EZH2 methyltransferase altamente selectivo con IC 50 12.6-17.4nM in vitro (células MM) e IC 50 9.9nM in vivo (ratones machos *ApoE-/-*)

  • GC17534 structure
    GC17534GSK343
    CAS: 1346704-33-3
    Purity: >98.00%

    A selective, cell-permeable EZH2 inhibitor

  • GC17907 structure
    GC179073-Deazaneplanocin A (DZNep) hydrochloride
    CAS: 120964-45-6
    Purity: >99.50%

    3-Deazaneplanocin A (DZNep) hydrochloride es un análogo de adenosina y es un inhibidor competitivo de la hidrolasa de S-adenosylhomocysteine con un Ki de 50 pM en pruebas libres de células.

  • GC14756 structure
    GC14756EI1
    CAS: 1418308-27-6
    Purity: >99.50%

    EI1 (KB-145943) es un inhibidor de EZH2 potente y selectivo con una IC50 de 15 nM y 13 nM para EZH2 (WT) y EZH2 (Y641F), respectivamente.

  • GC11484 structure
    GC11484CPI-169 S-enantiomer
    Purity: >98%

    EZH2 inhibitor

  • GC12146 structure
    GC12146CPI-169 R-enantiomer
    CAS: 1802175-07-0
    Purity: >98%

    EZH2 inhibitor

  • GC16599 structure
    GC16599CPI-169
    CAS: 1450655-76-1
    Purity: >98.00%

    EZH2 inhibitor