Fenipentol (1-Phenyl-1-pentanol), a synthetic derivative of an ingredient of Curcuma longa that is used as a condiment and dye. Fenipentol is also an orally active choleretic agent that plays an important role in release of secretin, gastrin, and pancreatic secretion of bicarbonate and protein[1][2][3].
Fenipentol (PHP) (50-200 mg/kg; p.o. and intraduodenal administration) increases the secretory volume of pancreatic juice and the output of protein in rats[2].Fenipentol (50-200 mg/kg for i.p. and 5-10 mg/kg for i.v.) considerably increases biliary secretion in rats[2].Fenipentol (25-200 mg/kg; intraduodenal administration) stimulates the pancreatic secretion in the canine[2].
[1]. Fregnan GB, et, al. Therapeutic properties of dihydroxy-dibutylether on sub-acute liver damage induced by several hepatotoxic agents in rats. Int J Tissue React. 1982; 4(4): 309-18. [2]. Wakabayashi T, et, al. [Effect of 1-phenyl-1-hydroxy-n-pentane on pancreatic secretion in the rat and the dog]. Nihon Yakurigaku Zasshi. 1971 Nov; 67(6): 637-47. [3]. Sharma A, et, al. Biocatalytic and electrochemical reduction of selected phenyl alkanones with antibacterial activity of the corresponding phenyl alkanols. Ijabpt Com, 2011.