E3 ligase Ligand 18 |
| Catalog No.GC35932 |
E3 ligase Ligand 18 es un ligando para E3 ubiquitina ligasa. El ligando 18 de E3 ligasa se puede conectar al ligando para proteÍna mediante un conector para formar PROTAC. Los PROTAC son inductores de la degradaciÓn mediada por ubiquitinaciÓn de proteÍnas promotoras del cÁncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2241669-88-3
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. VHL
[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
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