GPX4-IN-2 is a potent GPX4 inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer.
GPX4-IN-2 (compound 28) (0.0005-10 mM; 24 h) shows antiproliferative activity with IC50s of 0.004, 0.016, 2.9 µM for 786-O, SJSA-1, A431 cells, respectively[1].
GPX4-IN-2 (5 mg/kg for mouse, 2 mg/kg for rats; i.v.) shows a good pharmacokinetics profile in mice and rats[1].
References:
[1]. Chun Jiang, et al. Compounds with ferroptosis inducing activity and methods of their use. WO2020176757A1.