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HIV Protease

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Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

Products Related to HIV Protease(35)

  • GC10240 structure
    GC10240Atazanavir sulfate (BMS-232632-05)
    CAS: 229975-97-7
    Purity: >99.50%

    An inhibitor of HIV-1 protease

  • GC10794 structure
    GC10794BMS-626529
    CAS: 701213-36-7
    Purity: >99.00%

    An HIV-1 attachment inhibitor

  • GC11300 structure
    GC11300Fosamprenavir Calcium Salt
    CAS: 226700-81-8
    Purity: >98.00%

    A prodrug form of amprenavir

  • GC11974 structure
    GC11974Pepstatin A
    CAS: 26305-03-3
    Purity: >98.50%

    Pepstatin A es un inhibidor oralmente activo de las proteasas aspárticas, que es producido por actinomicetos.

  • GC12945 structure
    GC12945Atazanavir
    CAS: 198904-31-3
    Purity: >98%

    An inhibitor of HIV-1 protease

  • GC13716 structure
    GC13716Lopinavir
    CAS: 192725-17-0
    Purity: >99.00%

    A potent HIV-1 protease inhibitor

  • GC14084 structure
    GC14084Nelfinavir Mesylate
    CAS: 159989-65-8
    Purity: >99.00%

    Un inhibidor de la proteasa del VIH-1.

  • GC14152 structure
    GC14152Amprenavir (agenerase)
    CAS: 161814-49-9
    Purity: >98.00%

    A selective HIV protease inhibitor

  • GC14454 structure
    GC14454Tipranavir
    CAS: 174484-41-4
    Purity: >98.00%

    A nonpeptidic HIV protease inhibitor

  • GC15335 structure
    GC15335Saquinavir
    CAS: 127779-20-8
    Purity: >99.00%
  • GC15785 structure
    GC15785Saquinavir mesylate
    CAS: 149845-06-7
    Purity: >98.50%

    An HIV protease inhibitor

  • GC16602 structure
    GC16602Darunavir
    CAS: 206361-99-1
    Purity: >99.50%

    An HIV-1 protease inhibitor

  • GC17303 structure
    GC17303Ritonavir
    CAS: 155213-67-5
    Purity: >99.50%

    An HIV protease inhibitor

  • GC17709 structure
    GC17709Nelfinavir
    CAS: 159989-64-7
    Purity: >99.00%

    Nelfinavir es un inhibidor competitivo selectivo y no peptídico de la proteasa del HIV-1. Nelfinavir muestra una buena actividad in vitro contra las cepas del HIV-1

  • GC17942 structure
    GC17942Darunavir Ethanolate
    CAS: 635728-49-3
    Purity: >99.50%

    El etanolato de darunavir (Etanolato TMC114) es un potente inhibidor de la proteasa del VIH que se usa para tratar y prevenir el VIH/SIDA.

  • GC32013 structure
    GC32013L-689502
    CAS: 138483-63-3
    Purity: >98%

    L-689502 es un potente inhibidor de la proteasa del VIH-1 con una IC50 de 1 nM.

  • GC32327 structure
    GC32327PNU-103017
    CAS: 166335-18-8
    Purity: >98%

    PNU-103017 es un inhibidor de la proteasa del VIH.

  • GC33968 structure
    GC33968DPC-681 (DPH-153893)
    CAS: 284661-68-3
    Purity: >99.50%

    DPC-681 (DPH-153893) es un inhibidor potente y selectivo de la proteasa del VIH con IC90 para el VIH-1 de tipo salvaje de 4 a 40 nM.

  • GC36116 structure
    GC36116Ganoderic acid B
    CAS: 81907-61-1
    Purity: >98.00%

    El Ácido ganodérico B es un triterpeno aislado del hongo Ganoderma lucidum.

  • GC36120 structure
    GC36120Ganodermanondiol
    CAS: 107900-76-5
    Purity: >98%

    Ganodermanondiol es un inhibidor de la melanogénesis aislado del Ganoderma lucidum.

  • GC36309 structure
    GC36309Indinavir
    CAS: 150378-17-9
    Purity: >98%

    Indinavir (MK-639 base libre) es un inhibidor de la proteasa del VIH-1 selectivo y activo por vÍa oral con una Ki de 0,54 nM para PR.

  • GC36310 structure
    GC36310Indinavir sulfate
    CAS: 157810-81-6
    Purity: >99.50%

    El sulfato de indinavir (MK-639) es un inhibidor de la proteasa del VIH-1 selectivo y activo por vÍa oral con una Ki de 0,54 nM para PR.

  • GC36333 structure
    GC36333Isoescin IA
    CAS: 219944-39-5
    Purity: >98.50%

    La isoescina IA es una saponina triterpenoide aislada de las semillas de Aesculus chinensis.

  • GC36871 structure
    GC36871Pepstatin Ammonium
    Purity: >99.50%

    Pepstatin Ammonium es un inhibidor de la proteasa aspÁrtica especÍfico producido por actinomicetos, con IC50 de 4,5 nM, 6,2 nM, 150 nM, 290 nM, 520 nM y 260 nM para hemoglobina-pepsina, hemoglobina-proctasa, caseÍna-pepsina, caseÍna-proctasa, caseÍna -proteasa Ácida y hemoglobina-proteasa Ácida, respectivamente.