justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer.
justicidin A (0-2.5 μM; 6 days) inhibits cell growth in colorectal cancer cells with IC50 values of 0.110, 0.400, 0.020, 1.540 and 0.004 μM for HT-29, HCT 116, SiHa, MCF7 and T24 cells, respectively[1].justicidin A (0.75 and 5 μM; 0-72 h) induces apoptosis in colorectal cancer cells[1].justicidin A (0.75 and 5 μM; 0-72 h) induces the cleavage of caspases and their target proteins in human colorectal cancer cells[1].justicidin A (0.75 and 5 μM; 0-72 h) damages mitochondria and releases cyto c and Smac from mitochondria[1].justicidin A (0.75 and 5 μM; 0-96 h) decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria[1].
justicidin A (6.2 mg/kg; p.o.; daily, for 56 days) suppresses the growth of human colorectal cancer cells in mice[1].