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LAH4

Catalog No.GC34256

LAH4, una hélice alfa del antibiÓtico peptÍdico anfipÁtico diseÑado, exhibe potentes actividades antimicrobianas, de transfecciÓn de Ácidos nucleicos y de penetraciÓn celular.

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LAH4 Chemical Structure

Cas No.: 184776-51-0

Tamaño Precio Disponibilidad Cantidad
1mg
110,00 $
Disponible
5mg
441,00 $
Disponible
10mg
791,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

LAH4 is an antimicrobial peptide that strongly interacts with phospholipid membranes, exhibiting in vitro transfection efficiency.

LAH4 exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities[1]. LAH4 mediates the transport of functional β-galactosidase, a large tetrameric protein of about 0.5 MDa, into the cell interior[2]. At acidic pH, LAH4 has exhibited a high tendency to interact strongly with and be adsorbed on anionic membrane[3].

[1]. Perrone B, et al. Lipid interactions of LAH4, a peptide with antimicrobial and nucleic acid transfection activities. Eur Biophys J. 2014 Nov;43(10-11):499-507. [2]. Moulay G, et al. Histidine-rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo. J Pept Sci. 2017 Apr;23(4):320-328. [3]. Islami M, et al. Study of orientation and penetration of LAH4 into lipid bilayer membranes: pH and composition dependence. Chem Biol Drug Des. 2014 Aug;84(2):242-52.

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