Lenalidomide-OH |
| Catalog No.GC60223 |
Lenalidomida-OH es un anÁlogo del ligando de cereblon (CRBN) Lenalidomida para la ligasa de ubiquitina E3, y se utiliza en el reclutamiento de la proteÍna CRBN. La lenalidomida-OH se puede conectar al ligando de la proteÍna mediante un conector para formar PROTAC, como el degradador PROTAC BTK SJF620.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1416990-08-3
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 [1].
Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
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