Leonuriside A is a phenolic compound that can be isolated from Leonurus japonicus. Leonuriside A exhibits anti-inflammatory activity, which inhibits the iNOS -related inflammatory pathway in LPS -stimulated macrophages, thereby suppressing the production of nitric oxide ( NO ) with an IC50 of 15.6 μM. Leonuriside A can be used in studies of anti-inflammatory natural products and the molecular mechanisms of inflammation [1] [2] [3].
In Vitro, Leonuriside A (up to 50 μM; 30 min pretreatment, 24 h LPS incubation) inhibits nitric oxide production in LPS-stimulated RAW264.7 macrophages with an IC50 of 15.6 μM, with no significant cytotoxicity at concentrations up to 50 μM[2].
References:
[1]. Ba Vinh L, et al. Bioactive triterpene glycosides from the fruit of Stauntonia hexaphylla and insights into the molecular mechanism of its inflammatory effects. Bioorganic & medicinal chemistry letters. 2019 Aug 15;29(16):2085-2089.
[2]. Dang Hau Viet, et al. A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum, Journal of Chemistry, 2020, 7416973.
[3]. Minh TT. et al. Lignans from the stems of Clerodendrum inerme Gaertn. VJCH, 59: 187-191.
In Vitro, Leonuriside A (up to 50 μM; 30 min pretreatment, 24 h LPS incubation) inhibits nitric oxide production in LPS-stimulated RAW264.7 macrophages with an IC50 of 15.6 μM, with no significant cytotoxicity at concentrations up to 50 μM[2].
References:
[1]. Ba Vinh L, et al. Bioactive triterpene glycosides from the fruit of Stauntonia hexaphylla and insights into the molecular mechanism of its inflammatory effects. Bioorganic & medicinal chemistry letters. 2019 Aug 15;29(16):2085-2089.
[2]. Dang Hau Viet, et al. A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum, Journal of Chemistry, 2020, 7416973.
[3]. Minh TT. et al. Lignans from the stems of Clerodendrum inerme Gaertn. VJCH, 59: 187-191.