Pulchinenoside J is a lupane-type triterpenoid saponin and a complement system inhibitor that acts via the classical pathway. Pulchinenoside J can be isolated from the roots of Pulsatilla chinensis [1].
In Vitro, Pulchinenoside J (compound 4) (292.5 μM; 10 min) inhibits complement activation through the classical pathway in vitro using guinea pig serum and sensitized sheep erythrocytes, with a CP50 of 292.5 μM[1].
References:
[1]. Xu Q, et al. Lupane-type triterpenoidal saponins from Pulsatilla chinensis and their anticomplement activities through the classical pathway[J]. Planta medica, 2013, 79(06): 506-512.
In Vitro, Pulchinenoside J (compound 4) (292.5 μM; 10 min) inhibits complement activation through the classical pathway in vitro using guinea pig serum and sensitized sheep erythrocytes, with a CP50 of 292.5 μM[1].
References:
[1]. Xu Q, et al. Lupane-type triterpenoidal saponins from Pulsatilla chinensis and their anticomplement activities through the classical pathway[J]. Planta medica, 2013, 79(06): 506-512.