Innate Immunity

Arachidic acid is a long-chain saturated fatty acid that has been found in peanut butter and anaerobic fungi.

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3.

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells).

Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM).

Azido-FTY720 es un anÁlogo fotoactivable de FTY720.

BAY 61-3606 (hydrochloride) is a potent and selective inhibitor of Syk kinase with a K i value of 7.5nM.

BerteroÍna, un anÁlogo de sulforafano de origen natural, entre otros, un agente antimetastÁsico.

BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).

BMS 470539 (hydrochloride) es una sustancia que activa el receptor de melanocortina-1 (MC-1R) altamente selectivo y potente. En los ensayos de acunmulación de cAMP, sus valores EC 50 para MC1R humano y ratón son 16.8 y 11.6nM, respectivamente

C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide.

C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide.

C24:1 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids.

El campestanol es un fitosterol que se puede encontrar en los alimentos vegetales.

CAY10575 (Compuesto 8) es un inhibidor de IKK2 con un IC50 de 0,075 μM.

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2.

El inhibidor de Chk2 (compuesto 1) es un inhibidor potente y selectivo de la quinasa de punto de control 2 (Chk2), con IC50 de 13,5 nM y 220,4 nM para Chk2 y Chk1, respectivamente. El inhibidor de Chk2 puede provocar un fuerte efecto de radioprotecciÓn mediado por Chk2 dependiente de ataxia telangiectasia mutada (ATM).

Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol.

Corticostatin is a corticostatic peptide that has been found in human granulocytes.

CPI-268456 (compuesto 141) es un potente inhibidor de BRD4 con una IC50 de <0,5 μM.

Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine.

C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities.

Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP.

Deethylindanomycin is a polyether antibiotic that has been found in S.

Defensin HNP-1 is a peptide secreted by polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.