Innate Immunity

Defensin HNP-2 is a peptide with antimicrobial properties that is secreted by human polymorphonuclear leukocytes (PMNs).

Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.

Dehydroevodiamine is an alkaloid that has been isolated from E.

Diclofenac methyl ester is a hydrophobic prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac.

Diflapolin es un inhibidor dual altamente activo de proteÍna activadora de 5-lipoxigenasa (FLAP)/epÓxido hidrolasa soluble (sEH) con marcada eficacia antiinflamatoria y alta selectividad de objetivos.

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid.

Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.

EGA es un inhibidor selectivo de las vÍas de trÁfico de endosomol explotadas por mÚltiples toxinas y virus.

La folipastatina es un potente inhibidor de la fosfolipasa A2 con una IC50 de 39 μM.

Formoterol O-β-D-glucuronide is a metabolite of formoterol .

FTY720 es un modulador inmunológico que regula a la baja los receptores de esfingosina-1-fosfato (S1P), mejora la actividad del transportador de esfingosina ABCB1 y el transportador de leucotrienos C4 ABCC1 e inhibe la actividad de fosfolipasa A2 citosólica.

Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver.

Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit.

Ganirelix (acetato) (Ganirest) es un antagonista competitivo inyectable de la hormona liberadora de gonadotropina (GnRH).

Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).

GSK106 (clorhidrato) es un control inactivo para los inhibidores selectivos de PAD4, GSK484 y GSK199.

GSK-121 Trifluoroacetatos un inhibidor selectivo de PAD4.

GSK199 (hydrochloride) es un inhibidor de la peptidil arginina deiminasa 4 (PAD4) selectivo por vía oral activa y reversible con un valor de IC 50 de 200nM en ausencia de iones de calcio

La himeglusina, como antibiÓtico fÚngico de β-lactona, es un inhibidor de la HMG-CoA sintasa (IC50 = 0,12 μM).

Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling.

KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer).

KIN1400 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.

KT109 es un inhibidor potente y selectivo de isoformas de la diacilglicerol lipasa-β (DAGLβ) con una IC50 de 42 nM.

Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide that is lacking the fatty acyl group.