Reactive Oxygen Species
Read More about this categoryShow Less
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Products Related to Reactive Oxygen Species(505)
- GC44918SOTS-1 (technical grade)CAS: 223507-96-8Purity: >80.00%
Superoxide radical anion is a toxic by-product of mitochondrial respiration that is formed from approximately 1-4% of the oxygen metabolized by aerobic organisms.
- GC45059TMB (hydrochloride hydrate)CAS: 207738-08-7Purity: >98.00%
TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate.
- GC45066Tosyl Phenylalanyl Chloromethyl KetoneCAS: 402-71-1Purity: >97.00%
Tosyl Phenylalanyl Chloromethyl Ketone (L-1-Tosilamido-2-feniletil clorometil cetona; L-Tosyl Phenylalanyl Chloromethyl Ketone) es un potente inhibidor de serina proteasa que reacciona con el nÚcleo de uniÓn a la proteÍna de retinoblastoma (RB) de la proteÍna E7 del VPH-18 y elimina su capacidad de uniÓn a RB.
- GC45131Urotensin II (human) (trifluoroacetate salt)Purity: >95.00%
Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM).
- GC453373-HydroxyterphenyllinCAS: 66163-76-6Purity: >70.00%
La 3-hidroxiterfenillina es un metabolito de Aspergillus candidus. La 3-hidroxiterfenillina suprime la proliferaciÓn y causa citotoxicidad contra las células A2780/CP70 y OVCAR-3. La 3-hidroxiterfenilina induce la detenciÓn de la fase S y la apoptosis. La 3-hidroxiterfenilina tiene potencial para la investigaciÓn del cÁncer de ovario.
- GC45595Vulpinic AcidCAS: 521-52-8Purity: >98.00%
El Ácido vulpÍnico, un metabolito del liquen, disminuye la producciÓn de ROS inducida por H2O2, el estrés oxidativo y los daÑos relacionados con el estrés oxidativo en las células endoteliales de la vena umbilical humana (HUVEC).
- GC45777Peonidin 3-O-glucoside (chloride)CAS: 6906-39-4Purity: >97.00%
La peonidina 3-O-glucósido (cloruro), una antocianina, actúa como secretagogo de insulina.
- GC45917Leucettine L41CAS: 1112978-84-3Purity: >98.00%
La leucettina L41 es un potente inhibidor de la cinasa regulada por fosforilaciÓn de tirosina de doble especificidad 1A (DYRK1A), DYRK2, cinasa similar a CDC 1 (CLK1) y CLK3 (IC50s = 0,04, 0,035, 0,015 y 4,5 μM, respectivamente)[1 ].
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC44672 | PPHP | 87864-20-8 | >98.00% | |
PPHP is a substrate for the measurement of peroxidase enzymes. | ||||
| GC44860 | S1QEL1.1 | 897613-29-5 | >98.00% | |
S1QEL1.1 is a small molecule that suppresses superoxide production during reverse electron transport through the IQ site of the mitochondrial respiratory complex I (IC50 = 70 nM) without affecting oxidative phosphorylation. | ||||
| GC44918 | SOTS-1 (technical grade) | 223507-96-8 | >80.00% | |
Superoxide radical anion is a toxic by-product of mitochondrial respiration that is formed from approximately 1-4% of the oxygen metabolized by aerobic organisms. | ||||
| GC44947 | SRS16-86 | 1793052-96-6 | >98.00% | |
El compuesto SRS16-86 pertenece a la tercera generación de inhibidores de la ferroptosis del grupo de las ferrostatinas. | ||||
| GC44989 | TAN 420E | 91700-93-5 | >95.00% | |
TAN 420E is a bacterial metabolite originally isolated from Streptomyces. | ||||
| GC45010 | TEMPONE | 2896-70-0 | >98.00% | |
2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS). | ||||
| GC45059 | TMB (hydrochloride hydrate) | 207738-08-7 | >98.00% | |
TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate. | ||||
| GC45066 | Tosyl Phenylalanyl Chloromethyl Ketone | 402-71-1 | >97.00% | |
Tosyl Phenylalanyl Chloromethyl Ketone (L-1-Tosilamido-2-feniletil clorometil cetona; L-Tosyl Phenylalanyl Chloromethyl Ketone) es un potente inhibidor de serina proteasa que reacciona con el nÚcleo de uniÓn a la proteÍna de retinoblastoma (RB) de la proteÍna E7 del VPH-18 y elimina su capacidad de uniÓn a RB. | ||||
| GC45131 | Urotensin II (human) (trifluoroacetate salt) | - | >95.00% | |
Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM). | ||||
| GC45226 | β-BHC | 319-85-7 | 95.00% | |
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane. | ||||
| GC45248 | (-)-FINO2 | 869298-31-7 | >98.00% | |
(-)-FINO2 es un peróxido orgánico que puede inducir selectivamente la ferroptosis y se utiliza para estudiar los mecanismos de la ferroptosis y la terapia contra el cáncer | ||||
| GC45337 | 3-Hydroxyterphenyllin | 66163-76-6 | >70.00% | |
La 3-hidroxiterfenillina es un metabolito de Aspergillus candidus. La 3-hidroxiterfenillina suprime la proliferaciÓn y causa citotoxicidad contra las células A2780/CP70 y OVCAR-3. La 3-hidroxiterfenilina induce la detenciÓn de la fase S y la apoptosis. La 3-hidroxiterfenilina tiene potencial para la investigaciÓn del cÁncer de ovario. | ||||
| GC45357 | 5-Chlorouracil | 1820-81-1 | >98.00% | |
| ||||
| GC45379 | Alloxan (hydrate) | 2244-11-3 | >98.00% | |
| ||||
| GC45427 | Dihydrolycorine | 6271-21-2 | >98.00% | |
| ||||
| GC45513 | MGR1 | 2361529-46-4 | >98.00% | |
| ||||
| GC45578 | Thymohydroquinone | 2217-60-9 | >98.00% | |
| ||||
| GC45595 | Vulpinic Acid | 521-52-8 | >98.00% | |
El Ácido vulpÍnico, un metabolito del liquen, disminuye la producciÓn de ROS inducida por H2O2, el estrés oxidativo y los daÑos relacionados con el estrés oxidativo en las células endoteliales de la vena umbilical humana (HUVEC). | ||||
| GC45662 | Dieugenol | 4433-08-3 | >98.00% | |
A neolignan with antioxidative and antiparasitic activities | ||||
| GC45706 | GHK-Cu (acetate) | 300801-03-0 | >98.00% | |
A tripeptide-copper(II) complex | ||||
| GC45777 | Peonidin 3-O-glucoside (chloride) | 6906-39-4 | >97.00% | |
La peonidina 3-O-glucósido (cloruro), una antocianina, actúa como secretagogo de insulina. | ||||
| GC45820 | Balsalazide-d4 | - | >99.00% | |
La balsalazida-d4 es balsalazida marcada con deuterio. | ||||
| GC45877 | CYM 5478 | 870762-83-7 | >98.00% | |
CYM 5478 es un agonista de S1P2 potente y altamente selectivo con un EC50 de 119 nM en un ensayo de eliminación de TGFα. | ||||
| GC45917 | Leucettine L41 | 1112978-84-3 | >98.00% | |
La leucettina L41 es un potente inhibidor de la cinasa regulada por fosforilaciÓn de tirosina de doble especificidad 1A (DYRK1A), DYRK2, cinasa similar a CDC 1 (CLK1) y CLK3 (IC50s = 0,04, 0,035, 0,015 y 4,5 μM, respectivamente)[1 ]. | ||||