Alloxan (hydrate) |
| Catalog No.GC45379 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244-11-3
Sample solution is provided at 25 µL, 10mM.
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Alloxan is a toxin that selectively eliminates pancreatic β-cells in mice, rats, and certain other animals, and is used to model type 1 diabetes in humans.1 Reduction of alloxan within β-cells precedes the generation of reactive oxygen species, which in turn contribute to β-cell death.2 The dose of alloxan needed to destroy beta cells, and thus induce diabetes, depends on the animal species, route of administration, and nutritional status.2,3,4
References
1. Dunn, J.S., Duffy, E., Gilmour, M.K., et al. Further observations on the effects of alloxan on the pancreatic islets. Journal of Physiology 103(2), 233-243 (1944).
2. Szkudelski, T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50(6), 537-546 (2001).
3. Eizirik, D.L., Pipeleers, D.G., Ling, Z., et al. Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proceedings of the National Academy of Sciences of the United States of America 91(20), 9253-9256 (1994).
4. Tyberg, B., Andersson, A., and Borg, L.A. Species differences in susceptibility of transplanted and cultured pancreatic islets to the β-cell toxin alloxan. General and Comparative Endocrinology 122, 238-251 (2001).
| Cas No. | 2244-11-3 | SDF | |
| Canonical SMILES | O=C(C(C(N1)=O)=O)NC1=O.O | ||
| Formula | C4H2N2O4.H2O | M.Wt | 160.1 |
| Solubility | DMF: 5 mg/ml,DMSO: 5 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.2461 mL | 31.2305 mL | 62.461 mL |
| 5 mM | 1.2492 mL | 6.2461 mL | 12.4922 mL |
| 10 mM | 624.6 μL | 3.123 mL | 6.2461 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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