MAP4K

MAP4Ks (Mitogen-activated protein kinase kinase kinase kinases) belong to the mammalian Ste20-like family of serine/threonine kinases. MAP4K family members, including Hematopoietic progenitor kinase 1 (HPK1/MAP4K1), Germinal centre kinase (GCK/MAP4K2), Germinal centre kinase-like kinase (GLK/MAP4K3), HPK/GCK-like kinase (HGK/MAP4K4), Misshapen-like kinase 1 (MINK1/MAP4K6) and TRAF2 and NCK interacting kinase (TNIK/MAP4K7), as potent LATS1/2-activating kinases.

Overexpression or deletion of MAP4Ks affects the phosphorylation and activity of Large tumor suppressor 1/2 (LATS1/2, homologues of Wts) and Yes-associated protein (YAP) /transcriptional co-activator with PDZ-binding motif (TAZ). By acting in a LATS-dependent, but Mammalian Ste20-like kinases 1/2 (MST1/2, homologues of Hpo)-independent manner, MAP4Ks restrict the activity of YAP/TAZ by promoting their phosphorylation and inhibiting target gene expression. MAP4Ks are components of the Hippo pathway by directly phosphorylating and activating the LATS1/2 kinases.MAP4K2/4/6 and MST1/2 both belong to the STE20-like kinase family, and their kinase domains are highly homologous to one another. MAP4K4 acts through LATS to inhibit YAP and cell proliferation.

Products Related to MAP4K(27)

GC73887 INS018 055
CAS: 2828567-39-9
Purity: >99.00%
INS018 055 (compuesto 112) es un inhibidor de TNIK y MAP4K4 con valores de IC50 de 12-120, 12-120 nM, respectivamente.
GC79473 AT-051/43421517
CAS: 1241957-37-8
Purity: >99.50%
AT-051/43421517 is a cytoprotective agent and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 ( hPgk1 ).
GC79481 HPK1-IN-2 TFA
Purity: >99.50%
HPK1-IN-2 TFA is an orally active HPK1 inhibitor ( IC 50 < 0.05 µM) with antitumor activity.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC73887	INS018 055	2828567-39-9	>99.00%
GC73887	INS018 055 (compuesto 112) es un inhibidor de TNIK y MAP4K4 con valores de IC50 de 12-120, 12-120 nM, respectivamente.
GC79473	AT-051/43421517	1241957-37-8	>99.50%
GC79473	AT-051/43421517 is a cytoprotective agent and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 ( hPgk1 ).
GC79481	HPK1-IN-2 TFA	-	>99.50%
GC79481	HPK1-IN-2 TFA is an orally active HPK1 inhibitor ( IC 50 < 0.05 µM) with antitumor activity.