Acyltransferase
Read More about this categoryShow Less
DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.
DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.
Products Related to Acyltransferase(69)
- GC61888Pactimibe sulfateCAS: 608510-47-0Purity: >98.00%
El sulfato de pactimibe (CS-505) es un inhibidor dual de ACAT1/2 con IC50 de 4,9 μM y 3,0 μM, respectivamente.
- GC64687BMS-963272CAS: 1441057-15-3Purity: >99.00%
BMS-963272 es un potente inhibidor selectivo de MGAT2 (IC50 = 7,1 nM) para el tratamiento de trastornos metabÓlicos.
- GC65200Nevanimibe hydrochlorideCAS: 133825-81-7Purity: >98.00%
El clorhidrato de nevanimiba (clorhidrato de PD-132301) es un inhibidor selectivo y activo por vÍa oral de la acil-coenzima A:colesterol O-aciltransferasa 1 (ACAT1) con una EC50 de 9 nM. El clorhidrato de nevanimiba inhibe ACAT2 con un EC50 de 368 nM. El clorhidrato de nevanimiba induce la apoptosis celular y tiene el potencial para el cÁncer adrenocortical.
- GC71495LecimibideCAS: 130804-35-2
Lecimibide (DuP 128) es un potente y específico inhibide acil-coa: colesterol acetiltransferasa (ACAT) para la investigación de antihiperlipidemia.
- GC73626PF-07202954CAS: 2639372-47-5Purity: >97.00%
PF-07202954 es un inhibidor de la DGAT2 débilmente básico con una IC50 de 10 nM para la DGAT2 humana.
- GC74100EflucimibeCAS: 202340-45-2Purity: >99.50%
Eflucimibe (F 12511) es un nuevo inhibidel colesterol o-acil-coenzima a (ACAT).
- GC79554PF-06427878CAS: 1809064-23-0Purity: >98%
PF-06427878 is an orally active, selective liver-targeted diacylglycerol acyltransferase 2 ( DGAT2 ) inhibitor with IC 50 s of 99 nM and 202 nM for human and rat DGAT2, respectively.
- GC79555Ent-Calquiquelignan ECAS: 1292294-31-5Purity: >98%
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC50570 | ST 045849 | 442665-87-4 | >98.50% | |
ST 045849 es un inhibidor de la O-GlcNAc transferasa (OGT), con un valor de IC 50 de 53μM | ||||
| GC52256 | CAY10794 | 1231243-91-6 | >98.00% | |
An inhibitor of DGAT-1 | ||||
| GC52290 | (R)-HTS-3 | 2771208-83-2 | >98.00% | |
An inhibitor of LPCAT3 | ||||
| GC61631 | Pactimibe | 189198-30-9 | >98.00% | |
Pactimibe (base libre CS-505) es un inhibidor dual de ACAT1/2 con IC50 de 4,9 μM y 3,0 μM, respectivamente. | ||||
| GC61888 | Pactimibe sulfate | 608510-47-0 | >98.00% | |
El sulfato de pactimibe (CS-505) es un inhibidor dual de ACAT1/2 con IC50 de 4,9 μM y 3,0 μM, respectivamente. | ||||
| GC62428 | Ervogastat | 2186700-33-2 | >98.00% | |
| GC62744 | (Rac)-OSMI-1 | 2748153-92-4 | >96.00% | |
(Rac)-OSMI-1 es el racemato de OSMI-1. | ||||
| GC64687 | BMS-963272 | 1441057-15-3 | >99.00% | |
BMS-963272 es un potente inhibidor selectivo de MGAT2 (IC50 = 7,1 nM) para el tratamiento de trastornos metabÓlicos. | ||||
| GC65200 | Nevanimibe hydrochloride | 133825-81-7 | >98.00% | |
El clorhidrato de nevanimiba (clorhidrato de PD-132301) es un inhibidor selectivo y activo por vÍa oral de la acil-coenzima A:colesterol O-aciltransferasa 1 (ACAT1) con una EC50 de 9 nM. El clorhidrato de nevanimiba inhibe ACAT2 con un EC50 de 368 nM. El clorhidrato de nevanimiba induce la apoptosis celular y tiene el potencial para el cÁncer adrenocortical. | ||||
| GC70245 | CP-113818 | 135025-12-6 | >99.00% | |
CP-113818 es un potente inhibidor de la aciltransferasa de colesterol (ACAT). | ||||
| GC70746 | OSMI-2 | 2260542-60-5 | >98.00% | |
OSMI-2 (compuesto 1b) es un inhibide n-acetilglucosamina transferasa (OGT) permecelular. | ||||
| GC71495 | Lecimibide | 130804-35-2 | - | |
Lecimibide (DuP 128) es un potente y específico inhibide acil-coa: colesterol acetiltransferasa (ACAT) para la investigación de antihiperlipidemia. | ||||
| GC73626 | PF-07202954 | 2639372-47-5 | >97.00% | |
PF-07202954 es un inhibidor de la DGAT2 débilmente básico con una IC50 de 10 nM para la DGAT2 humana. | ||||
| GC74100 | Eflucimibe | 202340-45-2 | >99.50% | |
Eflucimibe (F 12511) es un nuevo inhibidel colesterol o-acil-coenzima a (ACAT). | ||||
| GC74105 | H2-003 | 1060438-30-3 | >99.00% | |
H2-003 es un inhibidor selectivo de la DGAT2 humana que inhila la biosíntesis de triglicéri(TG). | ||||
| GC79554 | PF-06427878 | 1809064-23-0 | >98% | |
PF-06427878 is an orally active, selective liver-targeted diacylglycerol acyltransferase 2 ( DGAT2 ) inhibitor with IC 50 s of 99 nM and 202 nM for human and rat DGAT2, respectively. | ||||
| GC79555 | Ent-Calquiquelignan E | 1292294-31-5 | >98% | |
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound. | ||||
| GC79556 | SPT-IN-2 | 2035011-97-1 | >99.00% | |
SPT-IN-2 is an orally active serine palmitoyltransferase ( SPT ) inhibitor (with an IC 50 of 0.71 nM against human SPT2 ). | ||||
| GC79557 | ST1060 | 1402702-76-4 | >96.50% | |
ST1060 is a Ceramide synthase 2 ( CerS2 ) inhibitor. | ||||
| GC79707 | ST1072 | 1402703-50-7 | >98% | |
ST1072 is an inhibitor of CerS4 and CerS6. | ||||
| GC90472 | Cyano-myracrylamide | 2801702-34-9 | >98.00% | |
Un inhibidor de zDHHC20 | ||||