GLPBio

Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

Products Related to Hedgehog(43)

  • GC39359 structure
    GC39359Ciliobrevin D
    CAS: 1370554-01-0
    Purity: >98.00%

    Ciliobrevin D es un inhibidor de la actividad de la dineína ATPase, que impide la actividad de ciclo de la proteína motora

  • GC43346 structure
    GC43346Cyclopamine-KAAD
    CAS: 306387-90-6
    Purity: >96.00%

    La ciclopamina-KAAD, un inhibidor de la seÑalizaciÓn hedgehog, es un antagonista suavizado.

  • GC43809 structure
    GC43809Hedgehog Antagonist VIII
    CAS: 330796-24-2
    Purity: >98.00%

    Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened.

  • GC44321 structure
    GC44321Nat-20(S)-yne
    CAS: 1397692-46-4
    Purity: >90.00%

    Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.

  • GC44458 structure
    GC44458N-Palmitoyl-L-Aspartate
    CAS: 1782-17-8
    Purity: >98.00%

    N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog.

  • GC44855 structure
    GC44855RU-SKI 43 (hydrochloride)
    CAS: 1782573-67-4
    Purity: >98.50%

    RU-SKI 43 (clorhidrato) es un inhibidor potente y selectivo de Hedgehog aciltransferasa (Hhat) con una IC50 de 850 nM. RU-SKI 43 (clorhidrato) reduce la activación de Gli-1 a través de la señalización no canónica independiente de Smoothened y disminuye la actividad de las vías Akt y mTOR. RU-SKI 43 (clorhidrato) tiene actividad anticancerígena.

  • GC45090 structure
    GC45090Triparanol
    CAS: 78-41-1
    Purity: >98.00%

    Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol.

  • GC47435 structure
    GC47435HPI-1 (hydrate)
    Purity: >95.00%

    A Hedgehog pathway inhibitor

  • GC47474 structure
    GC47474Itraconazole-d5
    CAS: 1217510-38-7
    Purity: >99.00%

    An internal standard for the quantification of itraconazole

  • GC47570 structure
    GC47570Lipoxygenin
    CAS: 2247911-68-6
    Purity: >98.00%

    An inhibitor of 5-LO

  • GC48062 structure
    GC48062RU-SKI 201 (hydrochloride)
    CAS: 2320262-09-5
    Purity: >95.00%

    A neuropeptide with diverse biological activities

  • GC49651 structure
    GC4965119-alkyne Cholesterol
    CAS: 2058319-71-2
    Purity: >95.00%

    Un derivado de alquino del colesterol para la química click.

  • GC64134 structure
    GC64134Hh-Ag1.5
    CAS: 612542-14-0
    Purity: >99.00%

    Hh-Ag1.5 (SAg1.5) es un potente agonista de Hedgehog (Hh) con una EC50 de 1 nM.

  • GC66390 structure
    GC663903-epi-Vitamin D3
    CAS: 57651-82-8
    Purity: >98%

    La 3-epi-vitamina D3 (epicolecalciferol) (compuesto 4), un anÁlogo de la vitamina D3, es un inhibidor de la vÍa Hedgehog con una IC50 de 39,2 μM medida en células U87MG.

  • GC72838 structure
    GC728381-Methyladenosine-d3 hydrochloride

    1-Methyladenosine-d3 hydrochloride es la forma de sal droclorde de deuterio etiquetado 1-metladenosina.

  • GC73310 structure
    GC73310SMO-IN-2
    CAS: 1822355-27-0
    Purity: >98.00%

    SMO-IN-2 (compuesto 1) es un potente inhibisuavi(SMO) con un valor de IC50 de 123,4 nM para la vía de señalización hedgehog (Hh).

  • GC73776 structure
    GC73776DS-1-38
    Purity: >99.00%

    DS-1-38 es un antagonista de EYA1 que bloquea la señalización Sonic Hedgehog (SHH).

  • GC74091 structure
    GC74091Itraconazole-d9
    CAS: 1309272-50-1
    Purity: >97.00%

    Itraconazole-d9 es el deuterio etiquetado itraconazol.

  • GC91424 structure
    GC91424S1PL-IN-31
    CAS: 1538574-95-6
    Purity: >98.00%

    S1PL-IN-31 es un inhibidor de la lisofosfolipasa de esfingosina-1-fosfato (S1P) (IC50 = 210 nM).