GLPBio

Survivin

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Survivin is the smallest member of the inhibitor of apoptosis (IAP) protein family, a family of highly conserved cell apoptosis inhibitors characterized by the presence of a zinc-binding fold (the baculoviral IAP repeat), that is comprised of a single N-terminal BIR domain, a long C-terminal α-helix coiled region and a dimeric arrangement. Survivin is a bifunctional protein, apart from its ability to inhibit apoptosis, which also plays an essential role in proper cell division. Survivin is not expressed in most normal and terminally differentiated adult tissues but expressed in fetal tissues, where its expression is cell cycle-regulated and peaks at mitosis.

Products Related to Survivin(12)

  • GC13107 structure
    GC13107YM155
    CAS: 781661-94-7
    Purity: >98.00%

    YM155, un pequeño compuesto a base de imidazolio, inhibe potentemente la actividad del promotor de la sorvivina con un valor de IC 50 de 0.54nM

  • GC15632 structure
    GC15632YM-155 hydrochloride
    CAS: 355406-09-6
    Purity: >98%

    A survivin inhibitor

  • GC33097 structure
    GC33097GDP366
    CAS: 501698-03-9
    Purity: >99.50%

    GDP366, un inhibidor dual de survivina y Op18, induce la inhibiciÓn del crecimiento celular, la senescencia celular y la catÁstrofe mitÓtica en las células cancerosas humanas.

  • GC35758 structure
    GC35758Cucurbitacin IIa
    CAS: 58546-34-2
    Purity: >99.00%

    La cucurbitacina IIa es un triterpeno aislado de Hemsleya amalils Diels, induce la apoptosis de las células cancerosas, reduce la expresiÓn de survivina, reduce la fosfohistona H3 y aumenta la PARP escindida en las células cancerosas.

  • GC60229 structure
    GC60229LQZ-7I
    CAS: 195822-23-2
    Purity: >99.50%

    LQZ-7I es un inhibidor dirigido a la survivina. LQZ-7I inhibe la dimerizaciÓn de survivina. LQZ-7I por vÍa oral inhibe eficazmente el crecimiento tumoral del xenoinjerto e induce la pérdida de survivina en los tumores.

  • GC69884 structure
    GC69884Shepherdin (79-87) (TFA)
    Purity: >98.00%

    Shepherdin (79-87) TFA es un fragmento de aminoácidos de Shepherdin que abarca del 79 al 87. Shepherdin es un antagonista peptídico del complejo Hsp90-Survivina. Tiene actividad antitumoral.

  • GC72933 structure
    GC72933LQZ-7F
    CAS: 354543-09-2
    Purity: >97.00%

    LQZ-7F, un inhibidor de la dimeride de supervivencia, induce apoptosis espontánea y sinergia con Docetaxel en células cancerosas de próstata.

  • GC73986 structure
    GC73986MX106-4C
    Purity: >98.00%

    MX106-4C es un inhibidor de la survivina que destruye selectivamente las células de cáncer colorrectal positivas a abcb1.

  • GC78967 structure
    GC78967ELTLGEFLKL
    CAS: 303068-29-3
    Purity: >99.00%

    ELTLGEFLKL is a survivin peptide.

  • GC79111 structure
    GC79111CK2-TN03
    CAS: 313226-24-3
    Purity: >98.00%

    CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM.

  • GC80875 structure
    GC80875PROTAC survivin degrader-1
    CAS: 3079079-69-6
    Purity: >98%

    PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC.

  • GC81531 structure
    GC81531PBX-7016
    CAS: 3003834-34-9
    Purity: >98.00%

    PBX-7016 is a DNA topoisomerase I inhibitor and DDX5 degrader.