ZINC00784494 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00784494 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00784494 has good potential for research in inflammatory breast cancer (IBC).
ZINC00784494 (0.01-100 µM; 72 h) reduces cell proliferation and cell viability in SUM149 cells[1].ZINC00784494 (1, 10 µM; 15 min, 1 h) reduces the p-Akt levels in SUM149 cells[1].
References:
[1]. Santiago-Sánchez GS, et al. Targeting Lipocalin-2 in Inflammatory Breast Cancer Cells with Small Interference RNA and Small Molecule Inhibitors. Int J Mol Sci. 2021 Aug 10;22(16):8581.