GLPBio

SPOP-IN-2

Catalog No.: GC73937
COASDSData Sheet
SPOP-IN-2 (compound E1) is a Speckle-type POZ protein (SPOP) inhibitor with IC50 of 0.58 μM, which disrupt the SPOP-subtrate interaction and selectively inhibits proliferation of ccRCC.

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SPOP-IN-2
Cas No.: 3031640-86-2
5 mgIn Stock
$153.00
1
10 mgIn Stock
$248.00
1
25 mgIn Stock
$495.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

SPOP-IN-2 (compound E1) is a Speckle-type POZ protein (SPOP) inhibitor with IC50 of 0.58 μM, which disrupt the SPOP-subtrate interaction and selectively inhibits proliferation of ccRCC.

SPOP-IN-2 (0-40 μM) binds to SPOPMATH protein through competition with puc-SBC1 peptide, disrupts the interaction between SPOPMATH and Myc-PTEN or Myc-DUSP7[1].SPOP-IN-2 (0-50 μM) selectively inhibits the colony formation of ccRCC in cell lines OS-RC-2, 786-O, A498, and 769-P[1].

References:
[1]. Zhou C, et al., Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP). ACS Med Chem Lett. 2024 Jan 25;15(2):270-279.

Product Documents

Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
3031640-86-2
Molecular Formula
C15H13ClN2O5S
Molecular Weight
368.79
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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