GLPBio

ST247

Catalog No.: GC70423
COASDSData Sheet
ST247 a potent PPARβ/δ inverse agonist.

Products are for research use only. Not for human use. We do not sell to patients.

ST247
Cas No.: 1356497-91-0
5 mgIn Stock
$180.00
1
10 mgIn Stock
$288.00
1
25 mgIn Stock
$531.00
1
50 mgIn Stock
$792.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    Nature
    641, 529–536 (2025)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ.

ST247 induces a clearly enhanced interaction of the PPARβ/δ LBD with the SMRT-ID2 peptide, with an EC50 of 10 nM[1].
ST247 down-regulates basal level expression of the peroxisome proliferator responsive element-driven PPARβ/δ target gene ANGPTL4, with an IC50 of 19.1 nM[1].

References:
[1]. Naruhn S, et al. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties. Mol Pharmacol. 2011 Nov;80(5):828-38.

Product Documents

Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1356497-91-0
Molecular Formula
C19H26N2O5S2
Molecular Weight
426.55
Solubility
DMSO : 200 mg/mL (468.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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