STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1].
G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts[1].G10 is an indirect activator of human STING-dependent phenotypes[1].G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling[1].STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity[1].G10 induces STING-dependent synthesis and secretion of bioactive interferon[1].G10 induces innate antiviral mRNA expression in primary human cells[1].
References:
[1]. Sali TM, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324.