GLPBio

Survivin

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Survivin is the smallest member of the inhibitor of apoptosis (IAP) protein family, a family of highly conserved cell apoptosis inhibitors characterized by the presence of a zinc-binding fold (the baculoviral IAP repeat), that is comprised of a single N-terminal BIR domain, a long C-terminal α-helix coiled region and a dimeric arrangement. Survivin is a bifunctional protein, apart from its ability to inhibit apoptosis, which also plays an essential role in proper cell division. Survivin is not expressed in most normal and terminally differentiated adult tissues but expressed in fetal tissues, where its expression is cell cycle-regulated and peaks at mitosis.

Products Related to Survivin(12)

  • GC13107 structure
    GC13107YM155
    CAS: 781661-94-7
    Purity: >98.00%

    YM155, a small imidazolium-based compound, potently inhibits survivin promoter activity with an IC 50 value of 0.54nM.

  • GC15632 structure
    GC15632YM-155 hydrochloride
    CAS: 355406-09-6
    Purity: >98%

    A survivin inhibitor

  • GC33097 structure
    GC33097GDP366
    CAS: 501698-03-9
    Purity: >99.50%

    GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.

  • GC35758 structure
    GC35758Cucurbitacin IIa
    CAS: 58546-34-2
    Purity: >99.00%

    Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells.

  • GC60229 structure
    GC60229LQZ-7I
    CAS: 195822-23-2
    Purity: >99.50%

    LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.

  • GC69884 structure
    GC69884Shepherdin (79-87) (TFA)
    Purity: >98.00%

    Shepherdin (79-87) TFA is a 79 to 87 amino acid fragment of Shepherdin. Shepherdin is a peptide antagonist of the Hsp90-Survivin complex and has anti-tumor activity.

  • GC72933 structure
    GC72933LQZ-7F
    CAS: 354543-09-2
    Purity: >97.00%

    LQZ-7F, a survivin dimerization inhibitor, induces spontaneous apoptosis and synergizes with Docetaxel in prostate cancer cells.

  • GC73986 structure
    GC73986MX106-4C
    Purity: >98.00%

    MX106-4C is a survivin inhibitor that selectively kills ABCB1-positive colorectal cancer cells.

  • GC78967 structure
    GC78967ELTLGEFLKL
    CAS: 303068-29-3
    Purity: >99.00%

    ELTLGEFLKL is a survivin peptide.

  • GC79111 structure
    GC79111CK2-TN03
    CAS: 313226-24-3
    Purity: >98.00%

    CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM.

  • GC80875 structure
    GC80875PROTAC survivin degrader-1
    CAS: 3079079-69-6
    Purity: >98%

    PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC.

  • GC81531 structure
    GC81531PBX-7016
    CAS: 3003834-34-9
    Purity: >98.00%

    PBX-7016 is a DNA topoisomerase I inhibitor and DDX5 degrader.