GLPBio

SYD5115

Catalog No.: GC71446
COASDSData Sheet
SYD5115 is an orally available TSH-R antagonist.

Products are for research use only. Not for human use. We do not sell to patients.

SYD5115
1 mgIn Stock
$270.00
1
5 mgIn Stock
$675.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

SYD5115 is an orally available TSH-R antagonist.

SYD5115 (0.1 nM-10 μM) blocks M22-induced cAMP production with IC50s of 22 nM in rat FRTL5 and HEK293-hTSHR cells, respectively[1] .
Note: M22 is a stimulating autoantibody to the human monoclonal TSH receptor (TSHR), and another autoantibody is K1-70 (blocking) [2].

References:
[1]. Karstens WFJ, et al. Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist. Bioorg Med Chem. 2023 Apr 15;84:117258.
[2]. Furmaniak J, et al. In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70). Auto Immun Highlights. 2011 Sep 14;3(1):19-25.

Product Documents

Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C22H32F2N4O3
Molecular Weight
438.51
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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