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TSH Receptor

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The thyrotropin receptor (TSHR), one of the primary antigens in autoimmune thyroid disease, is a target of both antigen-specific T cells and antibodies in patients with this condition. Autoantibodies to the TSHR (TSHR-Ab) act as thyroid stimulating factor (TSH) agonists in autoimmune hyperthyroidism (Robert Graves disease) but as TSH antagonists in autoimmune hypothyroidism (Hashimoto thyroiditis). The TSHR antigen is primarily expressed in the epithelial cells of the thyroid follicles, but TSHR mRNA and protein have been reported in a variety of cell types, some of which show evidence of receptor activity.

TSH receptor (TSHR) plays an important role in the pathogenesis of thyroid disease, a TSHR antagonist could be a novel treatment.

TSH, acting through the TSH receptor, is the major stimulator of thyroid cell growth, differentiation and function.

Products Related to TSH Receptor(10)

  • GC12956 structure
    GC12956ML224
    CAS: 1338824-21-7
    Purity: >98.50%

    selective TSHR inverse agonist

  • GC19543 structure
    GC19543NCGC00379308
    CAS: 662164-09-2
    Purity: >98%

    NCGC00379308 is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro.

  • GC26016 structure
    GC26016TSHR antagonist S37
    CAS: 1217616-61-9
    Purity: >98%

    TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).

  • GC31490 structure
    GC31490ML-109
    CAS: 1186649-91-1
    Purity: >99.00%

    ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

  • GC32423 structure
    GC32423Org41841
    CAS: 301847-37-0
    Purity: >99.00%

    Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.

  • GC62506 structure
    GC62506TSHR antagonist S37b
    CAS: 2143452-22-4
    Purity: >99.00%

    TSHR antagonist S37b is the less effective enantiomer of TSHR antagonist S37a.

  • GC62519 structure
    GC62519TSHR antagonist S37a
    CAS: 2143452-20-2
    Purity: >99.00%

    TSHR antagonist S37a is a highly selective thyrotropin receptor (TSHR) antagonist, with potential for the treatment of Graves' orbitopathy.

  • GC64079 structure
    GC64079NCGC00229600
    CAS: 1338824-20-6
    Purity: >99.00%

    NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR).

  • GC65946 structure
    GC65946VA-K-14 hydrochloride
    CAS: 1171341-19-7
    Purity: >98%

    VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM).

  • GC71446 structure
    GC71446SYD5115

    SYD5115 is an orally available TSH-R antagonist.