Target Protein Ligand-Linker Conjugate

Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein, a linker, which bring together E3 ubiquitin ligase and ubiquitinating machinery.

Products Related to Target Protein Ligand-Linker Conjugate(3)

GC38127 FAK ligand-Linker Conjugate 1
CAS: 2307461-45-4
Purity: >98.00%
FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation.
GC38778 ERRα Ligand-Linker Conjugates 1
Purity: >98%
GC39190 K-Ras ligand-Linker Conjugate 3
CAS: 2378261-87-9
Purity: >98%
K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be used in the synthesis of PROTAC K-Ras Degrader-1, which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC38127	FAK ligand-Linker Conjugate 1	2307461-45-4	>98.00%
GC38127	FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation.
GC38778	ERRα Ligand-Linker Conjugates 1	-	>98%
GC39190	K-Ras ligand-Linker Conjugate 3	2378261-87-9	>98%
GC39190	K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be used in the synthesis of PROTAC K-Ras Degrader-1, which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.