GLPBio

TCS 5861528

Catalog No.: GC11185Purity:>99.00%Synonyms: TCS 5861528
COASDSData Sheet
TCS 5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively.

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TCS 5861528
Cas No.: 332117-28-9
10mM (in 1mL DMSO)In Stock
$30.00
1
1mgIn Stock
$15.00
1
5mgIn Stock
$36.00
1
10mgIn Stock
$55.00
1
25mgIn Stock
$110.00
1
50mgIn Stock
$168.00
1
100mgIn Stock
$254.00
1
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Citations

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

Description

Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).

References:
[1]. Wei H, et al. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54.
[2]. Wei H, et al. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 2010 Mar;58(3):578-84.
[3]. Wei H, et al. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010 Aug 2;479(3):253-6.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
332117-28-9
Synonyms
TCS 5861528
Chemical Name
(R)-N-(4-(sec-butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetamide
SMILES
O=C1N(C)C(N(C)C(N=C2)=C1N2CC(NC3=CC=C(C=C3)[C@H](C)CC)=O)=O
Molecular Formula
C19H23N5O3
Molecular Weight
369.42
Solubility
≥ 76 mg/mL in DMSO with ultrasonic and warming, ≥ 6.17 mg/mL in EtOH with ultrasonic and warming
Storage
Store at RT
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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