GLPBio

Pyk2

Pyk2 is a nonreceptor cytoplasmic protein tyrosine kinase. It is involved in Ca(2+)-induced regulation of ion channel and MAP kinase activation. It plays a role in various cellular events such as cell motility, cell polarization, adhesion, reorganization of actin cytoskeleton etc.

Products Related to Pyk2(7)

  • GC10810 structure
    GC10810PF-562271 HCl
    CAS: 939791-41-0
    Purity: >98%

    PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively.

  • GC14407 structure
    GC14407PF-431396
    CAS: 717906-29-1
    Purity: >98.50%

    Pyk2 and FAK inhibitor

  • GC15380 structure
    GC15380PF-562271
    CAS: 717907-75-0
    Purity: >98.00%

    PF-562271 is a potent small-molecule inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) with a IC 50 of 1.5 and 14nmol/L, respectively.

  • GC14767 structure
    GC14767PF-00562271
    CAS: 939791-38-5
    Purity: >99.00%

    PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively.

  • GC16821 structure
    GC16821TAE226(NVP-TAE226)
    CAS: 761437-28-9
    Purity: >98.00%

    TAE226(NVP-TAE226) is a potent ATP-competitive inhibitor that inhibits a variety of tyrosine protein kinases, especially FAK and IGF-IR kinases, with IC 50 values ​​of 5.5nM and 140nM, respectively.

  • GC73424 structure
    GC73424PRT062607 acetate
    CAS: 1370261-98-5
    Purity: >99.00%

    PRT062607 (P505-15) acetate is an orally available Syk inhibitor (IC50: 1 nM) that inhibits inflammation and induction Apoptosis.

  • GC74116 structure
    GC74116Pyk2-IN-2
    CAS: 1271418-15-5
    Purity: >98.00%

    Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM.