TGF-β / Smad Signaling
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Targets for TGF-β / Smad Signaling
Products for TGF-β / Smad Signaling
- Cat.No. Product Name Information
-
GC62478
Ζ-Stat-2
-
GC13890
(±)-Palmitoylcarnitine chloride
intermediate in mitochondrial fatty acid oxidation
-
GC16081
(-)-epicatechin
inducer of pancreatic β-cell regeneration
-
GC10603
(-)-epicatechin gallate
major catechin in green tea
-
GC17242
(-)-epigallocatechin
green tea epicatechin
-
GC14049
(-)-Epigallocatechin gallate (EGCG)
Antioxidant, antiangiogenic and antitumor agent
-
GC14012
(-)-Indolactam V
A protein kinase C activator
-
GC18062
1,2-Dilauroyl-sn-glycerol
-
GC14134
1,2-Dimyristoyl-sn-glycerol
-
GC13877
1,2-Dipalmitoyl-sn-glycerol
weak activator of PKC
-
GC12662
1,2-Distearoyl-sn-glycerol
-
GC12172
1-Naphthyl PP1
Src family kinases inhibitor
-
GC41863
10,11-dehydro Curvularin
A natural mycotoxin
-
GN10444
12-O-tetradecanoyl phorbol-13-acetate
An activator of ERK/MAPK
-
GC13927
A 77-01
Potent ALK5 inhibitor
-
GC10166
A 83-01
ALK-5 inhibitor
-
GC35210
A 83-01 sodium salt
A potent inhibitor of TGF-β type I receptor ALK5 kinase
-
GC60037
A-3 hydrochloride
-
GC15579
Adaphostin
P210bcr/abl tyrosine kinase inhibitor
-
GC16475
Afuresertib
pan-AKT inhibitor
-
GC42747
Afuresertib (hydrochloride)
Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively.
-
GC11050
ALK5 Inhibitor II (hydrochloride)
ALK5 inhibitor
-
GC34300
AR-13324 analog mesylate
-
GC19034
AR-13324 mesylate
AR-13324 is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.
-
GC31959
AS2521780
-
GC32703
Asciminib (ABL001)
-
GN10534
Asiaticoside
Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.
-
GC10914
AST 487
RET kinase inhibitor
-
GC17712
AT13148
Multi-AGC kinase inhibitor,ATP-competitive
-
GC10638
AT9283
Aurora kinase/JAK inhibitor
-
GC50589
AZ 12799734
Potent TGF-βRI inhibitor
-
GC35442
Azaindole 1
-
GC35462
Bafetinib
Bcr-Abl/Lyn tyrosine kinase inhibitor
-
GC33343
BCR-ABL-IN-1
-
GC33368
BCR-ABL-IN-2
-
GC32868
BDP5290
-
GC34493
BIBF0775
-
GC62868
BIO-013077-01
-
GC12135
Bisindolylmaleimide II
protein kinase C (PKC) inhibitor
-
GC14716
Bisindolylmaleimide IV
protein kinase C (PKC) inhibitor
-
GC17239
Bisindolylmaleimide V
negative control for protein kinase C (PKC)-inhibitory activity
-
GC13226
Bisindolylmaleimide VIII (acetate)
A protein kinase C (PKC) inhibitor
-
GC18354
Bisindolylmaleimide X (hydrochloride)
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
-
GC35530
BJE6-106
-
GC50593
BMP signaling agonist sb4
Potent BMP4 agonist
-
GC13343
Bosutinib (SKI-606)
A potent inhibitor of Src and Abl kinases
-
GC40080
Bosutinib-d8
Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS.
-
GC17670
Bryostatin 1
PKC activator
-
GC12842
Bryostatin 2
Protein kinase C (PKC) activator
-
GC12695
Bryostatin 3
protein kinase C activator
-
GC16539
Butaprost
-
GC11605
C-1
protein kinase C inhibitor
-
GC43105
C8 Ceramide (d18:1.8:0)
A cell-permeable analog of naturally occurring ceramides
-
GC11159
Calphostin C
protein kinase C inhibitor
-
GC62612
CC-90005
-
GC38898
CCG-222740
-
GC18521
Cercosporin
Cercosporin is a pigmented phytotoxin isolated from the fungus C.
-
GC10687
CGP 53353
PKCβII inhibitor
-
GC14650
CGP60474
CDKs and PKC inhibitor, potent
-
GC32250
Chebulinic acid
-
GN10463
Chelerythrine
PKC inhibitor
-
GC13065
Chelerythrine Chloride
PKC antagonist
-
GC16097
chroman 1
ROCK II inhibitor, highly potent and selective
-
GC43286
CMPD101
A GRK2 and GRK3 inhibitor
-
GC50704
CRT 0066854 hydrochloride
-
GC45414
CRT0066854
-
GC33351
CZC-8004 (CZC-00008004)
-
GC17591
D-erythro-Sphingosine (synthetic)
protein kinase C and calmodulin-dependent enzymes inhibitor
-
GN10336
Daphnetin
Protein kinases inhibitor for EGFR/PKA/PKC
-
GC38186
Daphnoretin
A coumarin with diverse biological activities
-
GC15568
Dasatinib (BMS-354825)
Src and BCR-Abl inhibitor
-
GC35812
Dasatinib hydrochloride
A potent and dual AblWT/Src inhibitor
-
GC15884
Dasatinib Monohydrate
Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases.
-
GC14007
DCC-2036 (Rebastinib)
Bcr-Abl inhibitor
-
GC38388
DCPLA-ME
-
GC31892
Decursin ((+)-Decursin)
-
GC38085
Decursinol angelate
-
GC16354
Dequalinium Chloride
anti-tumor agent and PKC inhibitor
-
GC38482
Desmethylglycitein
-
GC17767
Dihydrosphingosine
Protein kinase C inhibitor
-
GC34060
Disitertide (P144)
An inhibitor of TGF-β1
-
GC60782
Disitertide TFA
-
GC14298
DMH-1
Selective BMP ALK2 receptor
-
GC17243
Dorsomorphin (Compound C)
AMPK inhibitor
-
GC12560
Dorsomorphin 2HCl
AMPK inhibitor
-
GC35897
DPH
A potent cell permeable c-Abl activator
-
GC32914
EMT inhibitor-1
-
GC11499
Enzastaurin (LY317615)
PKC beta inhibitor,potent and selective
-
GC13354
EW-7197
Selective inhibitor of TGF-β type I receptor kinase
-
GC13869
Fasudil
Calcium antagonist
-
GC14289
Fasudil (HA-1077) HCl
Protein kinase inhibitor
-
GC32867
Flumatinib (HHGV678)
-
GC13914
Flumatinib mesylate
PDGRFβ inhibitor
-
GC12027
FR 236924
PKC-ε activator, selective
-
GC15431
GF 109203X
Protein kinase C,MLCK,PKG and PKA inhibitor
-
GC10858
GNF 2
Bcr-Abl inhibitor
-
GC15079
GNF 5
Bcr-Abl inhibitor
-
GC10607
GNF-7
Type II Bcr-Abl inhibitor
-
GC15564
Go 6976
PKCα/PKCβ1 inhibitor
-
GC16907
Go 6983
A pan-PKC inhibitor