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Home >> Signaling Pathways >> TGF-β / Smad Signaling

TGF-β / Smad Signaling

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Targets for  TGF-β / Smad Signaling

Products for  TGF-β / Smad Signaling

  1. Cat.No. Product Name Information
  2. GC62478 Ζ-Stat-2 Ζ-Stat-2 Chemical Structure
  3. GC13890 (±)-Palmitoylcarnitine chloride intermediate in mitochondrial fatty acid oxidation (±)-Palmitoylcarnitine chloride Chemical Structure
  4. GC16081 (-)-epicatechin inducer of pancreatic β-cell regeneration (-)-epicatechin Chemical Structure
  5. GC10603 (-)-epicatechin gallate major catechin in green tea (-)-epicatechin gallate Chemical Structure
  6. GC17242 (-)-epigallocatechin green tea epicatechin (-)-epigallocatechin Chemical Structure
  7. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  8. GC14012 (-)-Indolactam V A protein kinase C activator (-)-Indolactam V Chemical Structure
  9. GC18062 1,2-Dilauroyl-sn-glycerol 1,2-Dilauroyl-sn-glycerol Chemical Structure
  10. GC14134 1,2-Dimyristoyl-sn-glycerol 1,2-Dimyristoyl-sn-glycerol Chemical Structure
  11. GC13877 1,2-Dipalmitoyl-sn-glycerol

    weak activator of PKC

     1,2-Dipalmitoyl-sn-glycerol Chemical Structure
  12. GC12662 1,2-Distearoyl-sn-glycerol 1,2-Distearoyl-sn-glycerol Chemical Structure
  13. GC12172 1-Naphthyl PP1 Src family kinases inhibitor 1-Naphthyl PP1 Chemical Structure
  14. GC41863 10,11-dehydro Curvularin A natural mycotoxin 10,11-dehydro Curvularin Chemical Structure
  15. GN10444 12-O-tetradecanoyl phorbol-13-acetate An activator of ERK/MAPK 12-O-tetradecanoyl phorbol-13-acetate Chemical Structure
  16. GC13927 A 77-01 Potent ALK5 inhibitor A 77-01 Chemical Structure
  17. GC10166 A 83-01 ALK-5 inhibitor A 83-01 Chemical Structure
  18. GC35210 A 83-01 sodium salt A potent inhibitor of TGF-β type I receptor ALK5 kinase A 83-01 sodium salt Chemical Structure
  19. GC60037 A-3 hydrochloride A-3 hydrochloride Chemical Structure
  20. GC15579 Adaphostin P210bcr/abl tyrosine kinase inhibitor Adaphostin Chemical Structure
  21. GC16475 Afuresertib pan-AKT inhibitor Afuresertib Chemical Structure
  22. GC42747 Afuresertib (hydrochloride) Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride) Chemical Structure
  23. GC11050 ALK5 Inhibitor II (hydrochloride) ALK5 inhibitor ALK5 Inhibitor II (hydrochloride) Chemical Structure
  24. GC34300 AR-13324 analog mesylate AR-13324 analog mesylate Chemical Structure
  25. GC19034 AR-13324 mesylate AR-13324 is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes. AR-13324 mesylate Chemical Structure
  26. GC31959 AS2521780 AS2521780 Chemical Structure
  27. GC32703 Asciminib (ABL001) Asciminib (ABL001) Chemical Structure
  28. GN10534 Asiaticoside Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns. Asiaticoside Chemical Structure
  29. GC10914 AST 487 RET kinase inhibitor AST 487 Chemical Structure
  30. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148 Chemical Structure
  31. GC10638 AT9283 Aurora kinase/JAK inhibitor AT9283 Chemical Structure
  32. GC50589 AZ 12799734 Potent TGF-βRI inhibitor AZ 12799734 Chemical Structure
  33. GC35442 Azaindole 1 Azaindole 1 Chemical Structure
  34. GC35462 Bafetinib

    Bcr-Abl/Lyn tyrosine kinase inhibitor

     Bafetinib Chemical Structure
  35. GC33343 BCR-ABL-IN-1 BCR-ABL-IN-1 Chemical Structure
  36. GC33368 BCR-ABL-IN-2 BCR-ABL-IN-2 Chemical Structure
  37. GC32868 BDP5290 BDP5290 Chemical Structure
  38. GC34493 BIBF0775 BIBF0775 Chemical Structure
  39. GC62868 BIO-013077-01 BIO-013077-01 Chemical Structure
  40. GC12135 Bisindolylmaleimide II protein kinase C (PKC) inhibitor Bisindolylmaleimide II Chemical Structure
  41. GC14716 Bisindolylmaleimide IV protein kinase C (PKC) inhibitor Bisindolylmaleimide IV Chemical Structure
  42. GC17239 Bisindolylmaleimide V negative control for protein kinase C (PKC)-inhibitory activity Bisindolylmaleimide V Chemical Structure
  43. GC13226 Bisindolylmaleimide VIII (acetate) A protein kinase C (PKC) inhibitor Bisindolylmaleimide VIII (acetate) Chemical Structure
  44. GC18354 Bisindolylmaleimide X (hydrochloride) Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). Bisindolylmaleimide X (hydrochloride) Chemical Structure
  45. GC35530 BJE6-106 BJE6-106 Chemical Structure
  46. GC50593 BMP signaling agonist sb4

    Potent BMP4 agonist

     BMP signaling agonist sb4 Chemical Structure
  47. GC13343 Bosutinib (SKI-606) A potent inhibitor of Src and Abl kinases Bosutinib (SKI-606) Chemical Structure
  48. GC40080 Bosutinib-d8 Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS. Bosutinib-d8 Chemical Structure
  49. GC17670 Bryostatin 1 PKC activator Bryostatin 1 Chemical Structure
  50. GC12842 Bryostatin 2 Protein kinase C (PKC) activator Bryostatin 2 Chemical Structure
  51. GC12695 Bryostatin 3 protein kinase C activator Bryostatin 3 Chemical Structure
  52. GC16539 Butaprost Butaprost Chemical Structure
  53. GC11605 C-1 protein kinase C inhibitor C-1 Chemical Structure
  54. GC43105 C8 Ceramide (d18:1.8:0)

    A cell-permeable analog of naturally occurring ceramides

     C8 Ceramide (d18:1.8:0) Chemical Structure
  55. GC11159 Calphostin C

    protein kinase C inhibitor

     Calphostin C Chemical Structure
  56. GC62612 CC-90005 CC-90005 Chemical Structure
  57. GC38898 CCG-222740 CCG-222740 Chemical Structure
  58. GC18521 Cercosporin Cercosporin is a pigmented phytotoxin isolated from the fungus C. Cercosporin Chemical Structure
  59. GC10687 CGP 53353 PKCβII inhibitor CGP 53353 Chemical Structure
  60. GC14650 CGP60474 CDKs and PKC inhibitor, potent CGP60474 Chemical Structure
  61. GC32250 Chebulinic acid Chebulinic acid Chemical Structure
  62. GN10463 Chelerythrine PKC inhibitor Chelerythrine Chemical Structure
  63. GC13065 Chelerythrine Chloride PKC antagonist Chelerythrine Chloride Chemical Structure
  64. GC16097 chroman 1 ROCK II inhibitor, highly potent and selective chroman 1 Chemical Structure
  65. GC43286 CMPD101 A GRK2 and GRK3 inhibitor CMPD101 Chemical Structure
  66. GC50704 CRT 0066854 hydrochloride CRT 0066854 hydrochloride Chemical Structure
  67. GC45414 CRT0066854   CRT0066854 Chemical Structure
  68. GC33351 CZC-8004 (CZC-00008004) CZC-8004 (CZC-00008004) Chemical Structure
  69. GC17591 D-erythro-Sphingosine (synthetic) protein kinase C and calmodulin-dependent enzymes inhibitor D-erythro-Sphingosine (synthetic) Chemical Structure
  70. GN10336 Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC Daphnetin Chemical Structure
  71. GC38186 Daphnoretin A coumarin with diverse biological activities Daphnoretin Chemical Structure
  72. GC15568 Dasatinib (BMS-354825) Src and BCR-Abl inhibitor Dasatinib (BMS-354825) Chemical Structure
  73. GC35812 Dasatinib hydrochloride A potent and dual AblWT/Src inhibitor Dasatinib hydrochloride Chemical Structure
  74. GC15884 Dasatinib Monohydrate Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases. Dasatinib Monohydrate Chemical Structure
  75. GC14007 DCC-2036 (Rebastinib) Bcr-Abl inhibitor DCC-2036 (Rebastinib) Chemical Structure
  76. GC38388 DCPLA-ME DCPLA-ME Chemical Structure
  77. GC31892 Decursin ((+)-Decursin) Decursin ((+)-Decursin) Chemical Structure
  78. GC38085 Decursinol angelate Decursinol angelate Chemical Structure
  79. GC16354 Dequalinium Chloride anti-tumor agent and PKC inhibitor Dequalinium Chloride Chemical Structure
  80. GC38482 Desmethylglycitein Desmethylglycitein Chemical Structure
  81. GC17767 Dihydrosphingosine

    Protein kinase C inhibitor

     Dihydrosphingosine Chemical Structure
  82. GC34060 Disitertide (P144)

    An inhibitor of TGF-β1

     Disitertide (P144) Chemical Structure
  83. GC60782 Disitertide TFA Disitertide TFA Chemical Structure
  84. GC14298 DMH-1 Selective BMP ALK2 receptor DMH-1 Chemical Structure
  85. GC17243 Dorsomorphin (Compound C) AMPK inhibitor Dorsomorphin (Compound C) Chemical Structure
  86. GC12560 Dorsomorphin 2HCl AMPK inhibitor Dorsomorphin 2HCl Chemical Structure
  87. GC35897 DPH A potent cell permeable c-Abl activator DPH Chemical Structure
  88. GC32914 EMT inhibitor-1 EMT inhibitor-1 Chemical Structure
  89. GC11499 Enzastaurin (LY317615) PKC beta inhibitor,potent and selective Enzastaurin (LY317615) Chemical Structure
  90. GC13354 EW-7197 Selective inhibitor of TGF-β type I receptor kinase EW-7197 Chemical Structure
  91. GC13869 Fasudil Calcium antagonist Fasudil Chemical Structure
  92. GC14289 Fasudil (HA-1077) HCl Protein kinase inhibitor Fasudil (HA-1077) HCl Chemical Structure
  93. GC32867 Flumatinib (HHGV678) Flumatinib (HHGV678) Chemical Structure
  94. GC13914 Flumatinib mesylate PDGRFβ inhibitor Flumatinib mesylate Chemical Structure
  95. GC12027 FR 236924 PKC-ε activator, selective FR 236924 Chemical Structure
  96. GC15431 GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor GF 109203X Chemical Structure
  97. GC10858 GNF 2 Bcr-Abl inhibitor GNF 2 Chemical Structure
  98. GC15079 GNF 5 Bcr-Abl inhibitor GNF 5 Chemical Structure
  99. GC10607 GNF-7

    Type II Bcr-Abl inhibitor

     GNF-7 Chemical Structure
  100. GC15564 Go 6976 PKCα/PKCβ1 inhibitor Go 6976 Chemical Structure
  101. GC16907 Go 6983 A pan-PKC inhibitor Go 6983 Chemical Structure

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