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Home >> Signaling Pathways >> TGF-β / Smad Signaling

TGF-β / Smad Signaling

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Targets for  TGF-β / Smad Signaling

Products for  TGF-β / Smad Signaling

  1. Cat.No. Product Name Information
  2. GC13890 (±)-Palmitoylcarnitine chloride

    C16:0 Carnitine, CAR 16:0, DL-Carnitine hexadecanoyl ester, DL-Carnitine palmitoyl ester, Hexadecanoyl-DL-carnitine, DL-Hexadecanoylcarnitine, NSC 628323, DL-Palmitoylcarnitine

     intermediate in mitochondrial fatty acid oxidation (±)-Palmitoylcarnitine chloride Chemical Structure
  3. GC10603 (-)-epicatechin gallate

    ECG

     major catechin in green tea (-)-epicatechin gallate Chemical Structure
  4. GC17242 (-)-epigallocatechin

    (-)EGC, epi-Gallocatechin, NSC 674039

     green tea epicatechin (-)-epigallocatechin Chemical Structure
  5. GC14049 (-)-Epigallocatechin gallate (EGCG)

    EGCG

     (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  6. GC14012 (-)-Indolactam V A protein kinase C activator (-)-Indolactam V Chemical Structure
  7. GC70295 (S)-Ro 32-0432 (S)-Ro 32-0432 is a potent, selective, ATP-competitive and orally active PKC inhibitor. (S)-Ro 32-0432 Chemical Structure
  8. GC18062 1,2-Dilauroyl-sn-glycerol

    1,2-DLG

     A longchain DAG 1,2-Dilauroyl-sn-glycerol Chemical Structure
  9. GC14134 1,2-Dimyristoyl-sn-glycerol

    1,2-DMG

     A longchain DAG 1,2-Dimyristoyl-sn-glycerol Chemical Structure
  10. GC13877 1,2-Dipalmitoyl-sn-glycerol

    1,2-DPG,NSC 269964

    weak activator of PKC

     1,2-Dipalmitoyl-sn-glycerol Chemical Structure
  11. GC12662 1,2-Distearoyl-sn-glycerol

    1,2-Dioctadecanoyl-sn-glycerol,DSG

     A diacylglycerol 1,2-Distearoyl-sn-glycerol Chemical Structure
  12. GC12172 1-Naphthyl PP1

    1NaphthylPP1, PP1 Analog

     Src family kinases inhibitor 1-Naphthyl PP1 Chemical Structure
  13. GC41863 10,11-dehydro Curvularin

    α,β-dehydro Curvularin

     A natural mycotoxin 10,11-dehydro Curvularin Chemical Structure
  14. GN10444 12-O-tetradecanoyl phorbol-13-acetate

    PMA; TPA; Phorbol myristate acetate

    A PKC activator

     12-O-tetradecanoyl phorbol-13-acetate Chemical Structure
  15. GC73085 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 3-droxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles Chemical Structure
  16. GC13927 A 77-01

    A77-01;A-77-01

     A potent ALK5 inhibitor A 77-01 Chemical Structure
  17. GC10166 A 83-01 A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 s of 12 nM,45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively . A 83-01 Chemical Structure
  18. GC35210 A 83-01 sodium salt

    3-(6-Methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide, sodium salt

    A potent inhibitor of TGF-β type I receptor ALK5 kinase

     A 83-01 sodium salt Chemical Structure
  19. GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride Chemical Structure
  20. GC15579 Adaphostin

    NSC 680410

     P210bcr/abl tyrosine kinase inhibitor Adaphostin Chemical Structure
  21. GC16475 Afuresertib

    GSK2110183

     pan-AKT inhibitor Afuresertib Chemical Structure
  22. GC42747 Afuresertib (hydrochloride)

    GSK2110183B

     Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride) Chemical Structure
  23. GC73739 AKE-72 AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 Chemical Structure
  24. GC65294 ALK2-IN-2 ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3. ALK2-IN-2 Chemical Structure
  25. GC11050 ALK5 Inhibitor II (hydrochloride)

    E 616452,RepSox,SJN 2511

     ALK5 inhibitor ALK5 Inhibitor II (hydrochloride) Chemical Structure
  26. GC73338 ALK5-IN-34 ALK5-IN-34 is an selective orally active activin receptor-like kinase (ALK) inhibitor. ALK5-IN-34 Chemical Structure
  27. GC68679 Aprinocarsen sodium

    ISIS 3521 sodium

    Aprinocarsen (ISIS 3521) sodium is a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-alpha). Aprinocarsen sodium is a 20-mer oligonucleotide that can regulate cell differentiation and proliferation. It can inhibit the growth of human tumor cell lines in nude mice. Aprinocarsen sodium has value as a chemotherapy compound for human cancer.

     Aprinocarsen sodium Chemical Structure
  28. GC34300 AR-13324 analog mesylate AR-13324 analog mesylate Chemical Structure
  29. GC19034 AR-13324 mesylate AR-13324 is a potent inhibitor of ROCK I and ROCK II that has been shown to induce morphologic changes in cultured human and porcine TM cells at low concentration. AR-13324 mesylate Chemical Structure
  30. GC31959 AS2521780 AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM. AS2521780 Chemical Structure
  31. GC32703 Asciminib (ABL001)

    ABL001

     Asciminib (ABL001) (ABL001) is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. Asciminib (ABL001) Chemical Structure
  32. GC64462 Asciminib hydrochloride Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. Asciminib hydrochloride Chemical Structure
  33. GN10534 Asiaticoside

    Ba 2742, NSC 36002, NSC 166062

     Asiaticoside Chemical Structure
  34. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148 Chemical Structure
  35. GC64815 Aurothiomalate sodium Aurothiomalate sodium is a potent and selective oncogenic PKCι signaling inhibitor. Aurothiomalate sodium Chemical Structure
  36. GC50589 AZ 12799734 Potent TGF-βRI inhibitor AZ 12799734 Chemical Structure
  37. GC35442 Azaindole 1

    ROCK-IN-2 ，TC-S 7001

     Azaindole 1 (Azaindole 1; TC-S 7001) is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1nM for human ROCK-1 and ROCK-2, respectively. Azaindole 1 Chemical Structure
  38. GC35462 Bafetinib

    INNO-406

    Bcr-Abl/Lyn tyrosine kinase inhibitor

     Bafetinib Chemical Structure
  39. GC33343 BCR-ABL-IN-1 BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia. BCR-ABL-IN-1 Chemical Structure
  40. GC33368 BCR-ABL-IN-2 BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively. BCR-ABL-IN-2 Chemical Structure
  41. GC73614 BCR-ABL-IN-8 BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor containing trimethoxy group. BCR-ABL-IN-8 Chemical Structure
  42. GC32868 BDP5290 BDP5290 is a potent inhibitor of ROCK and MRCK with IC50 values of 17nM, 230nM, 123nM and 100nM for MRCKβ, ROCK1, ROCK2, respectively. BDP5290 Chemical Structure
  43. GC34493 BIBF0775 BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM. BIBF0775 Chemical Structure
  44. GC74516 Bintrafusp alfa

    M7824; MSB0011359C

     Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa Chemical Structure
  45. GC62868 BIO-013077-01 BIO-013077-01 is a pyrazole TGF-β inhibitor. BIO-013077-01 Chemical Structure
  46. GC12135 Bisindolylmaleimide II

    BIM II

     protein kinase C (PKC) inhibitor Bisindolylmaleimide II Chemical Structure
  47. GC14716 Bisindolylmaleimide IV

    Arcyriarubin A,BIM IV

     protein kinase C (PKC) inhibitor Bisindolylmaleimide IV Chemical Structure
  48. GC17239 Bisindolylmaleimide V

    BIM V, Ro 316045

     negative control for protein kinase C (PKC)-inhibitory activity Bisindolylmaleimide V Chemical Structure
  49. GC13226 Bisindolylmaleimide VIII (acetate)

    BIM VIII,Ro 31-7549

     A protein kinase C (PKC) inhibitor Bisindolylmaleimide VIII (acetate) Chemical Structure
  50. GC18354 Bisindolylmaleimide X (hydrochloride)

    BIM X, Ro 31-8425

     Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). Bisindolylmaleimide X (hydrochloride) Chemical Structure
  51. GC35530 BJE6-106

    B106

     BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 Chemical Structure
  52. GC50593 BMP signaling agonist sb4

    Potent BMP4 agonist

     BMP signaling agonist sb4 Chemical Structure
  53. GC73535 BMPR2-IN-1 TFA

    BMPR2-IN-1 (Compound 8a) is a BMPR2 inhibitor with an IC50 of 506 nM and a KD of 83.5 nM.

     BMPR2-IN-1 TFA Chemical Structure
  54. GC13343 Bosutinib (SKI-606)

    SKI 606

     Bosutinib (SKI-606) is an oral Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively. Bosutinib (SKI-606) Chemical Structure
  55. GC40080 Bosutinib-d8

    SKI-606 D8

     Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS. Bosutinib-d8 Chemical Structure
  56. GC17670 Bryostatin 1

    NSC 339555

     PKC activator Bryostatin 1 Chemical Structure
  57. GC12842 Bryostatin 2 Protein kinase C (PKC) activator Bryostatin 2 Chemical Structure
  58. GC12695 Bryostatin 3 protein kinase C activator Bryostatin 3 Chemical Structure
  59. GC72917 BUR1 BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 Chemical Structure
  60. GC16539 Butaprost

    15deoxy16Shydroxy17cyclobutyl PGE1 methyl ester, TR 4979

     A selective agonist for the EP2 receptors Butaprost Chemical Structure
  61. GC11605 C-1 C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor. C-1 Chemical Structure
  62. GC43105 C8 Ceramide (d18:1.8:0)

    N-octanoyl-D-erythro-Sphingosine

     C8 Ceramide (d18:1.8:0) (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8 Ceramide (d18:1.8:0) Chemical Structure
  63. GC11159 Calphostin C

    Cladochrome E, PKF 115584, UCN 1028C

    protein kinase C inhibitor

     Calphostin C Chemical Structure
  64. GC68833 Carotuximab

    TRC105; DE-122

    Carotuximab (TRC105) is an IgG1 monoclonal antibody that can block endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and anti-tumor effects.

     Carotuximab Chemical Structure
  65. GC43184 CAY10622 Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. CAY10622 Chemical Structure
  66. GC62612 CC-90005 CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 Chemical Structure
  67. GC38898 CCG-222740 CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis. CCG-222740 Chemical Structure
  68. GC73183 CDK8-IN-12 CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM. CDK8-IN-12 Chemical Structure
  69. GC35651 Cenisertib

    AS-703569; R-763

     Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia. Cenisertib Chemical Structure
  70. GC18521 Cercosporin

    CGP 049090, NSC 153111

     Cercosporin is a pigmented phytotoxin isolated from the fungus C. Cercosporin Chemical Structure
  71. GC10687 CGP 53353

    DAPH-7

     PKCβII inhibitor CGP 53353 Chemical Structure
  72. GC14650 CGP60474 A CDK inhibitor CGP60474 Chemical Structure
  73. GC32250 Chebulinic acid

    Eutannin, NSC 69862

     An ellagitannin with diverse biological activities Chebulinic acid Chemical Structure
  74. GN10463 Chelerythrine Chelerythrine Chemical Structure
  75. GC13065 Chelerythrine Chloride

    Broussonpapyrine chloride, NSC 646662

     Potent inhibitor of PKC and Bcl-xL Chelerythrine Chloride Chemical Structure
  76. GC35682 CHMFL-ABL/KIT-155

    CHMFL-ABL-KIT-155

     CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM) and PDGFRβ (IC50=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis. CHMFL-ABL/KIT-155 Chemical Structure
  77. GC71281 Chroman 1 dihydrochloride Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride Chemical Structure
  78. GC70882 Chromenone 1 Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 Chemical Structure
  79. GC43286 CMPD101 A GRK2 and GRK3 inhibitor CMPD101 Chemical Structure
  80. GC50704 CRT 0066854 hydrochloride CRT 0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT 0066854 hydrochloride Chemical Structure
  81. GC45414 CRT0066854   CRT0066854 Chemical Structure
  82. GC35753 CT-721 CT-721 is a potent and time-dependent Bcr-Abl kinase inhibitor with an IC50 of 21.3 nM for wild-type Bcr-Abl kinase, and possesses anti-chronic myeloid leukemia (CML) activities. CT-721 Chemical Structure
  83. GC33351 CZC-8004 (CZC-00008004)

    Dianilinopyrimidine-01

     CZC-8004 (CZC-00008004) (CZC-00008004), an aminopyrimidine, is a pan-kinase inhibitor. CZC-8004 (CZC-00008004) can bind a range of tyrosine kinases, including EGFR and VEGFR2 with IC50 values of 650 and 437 nM, respectively. CZC-8004 (CZC-00008004) Chemical Structure
  84. GC17591 D-erythro-Sphingosine (synthetic)

    (-)Sphingosine, DerythroSphingosine C18

     D-erythro-sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 value of 8μM. D-erythro-Sphingosine (synthetic) Chemical Structure
  85. GC72448 Dalutrafusp alfa Dalutrafusp alfa (AGEN-1423; GS-1423) is a specific bifunctional antibody against CD73 and TGF-β, which is involved in the immunosuppressive pathway. Dalutrafusp alfa Chemical Structure
  86. GN10336 Daphnetin

    7,8-Dihydroxycoumarin, NSC 633563

     Daphnetin Chemical Structure
  87. GC38186 Daphnoretin

    NSC 291852

     A coumarin with diverse biological activities Daphnoretin Chemical Structure
  88. GC35812 Dasatinib hydrochloride A potent and dual AblWT/Src inhibitor Dasatinib hydrochloride Chemical Structure
  89. GC15884 Dasatinib Monohydrate Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases. Dasatinib Monohydrate Chemical Structure
  90. GC14007 DCC-2036 (Rebastinib)

    DCC-2036

     DCC-2036 (Rebastinib) (DCC-2036) is an orally active, non-ATP-competitiveBcr-Abl inhibitor for Abl1WT and Abl1T315I with IC50s of 0.8 nM and 4 nM, respectively. DCC-2036 (Rebastinib) also inhibits SRC, KDR, FLT3, and Tie-2, and has low activity to seen towards c-Kit. DCC-2036 (Rebastinib) Chemical Structure
  91. GC38388 DCPLA-ME

    DCPLA methyl ester

     DCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases. DCPLA-ME Chemical Structure
  92. GC31892 Decursin ((+)-Decursin)

    (+)-Decursin

     Decursin ((+)-Decursin) ((+)-Decursin ((+)-Decursin)) is a potent anti-tumor agent. Decursin ((+)-Decursin) Chemical Structure
  93. GC38085 Decursinol angelate Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities. Decursinol angelate Chemical Structure
  94. GC16354 Dequalinium Chloride

    NSC 166454

     anti-tumor agent and PKC inhibitor Dequalinium Chloride Chemical Structure
  95. GC38482 Desmethylglycitein

    6-hydroxy Daidzein, 6,7,4’-THIF

     Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities.Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes. Desmethylglycitein Chemical Structure
  96. GC17767 Dihydrosphingosine Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2). Dihydrosphingosine Chemical Structure
  97. GC34060 Disitertide (P144) Disitertide (P144) (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) (P144) is also a PI3K inhibitor and an apoptosis inducer. Disitertide (P144) Chemical Structure
  98. GC68333 Disitertide diammonium

    P144 diammonium

     Disitertide diammonium Chemical Structure
  99. GC60782 Disitertide TFA

    P144 TFA

     Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) TFA is also a PI3K inhibitor and an apoptosis inducer. Disitertide TFA Chemical Structure
  100. GC72959 DJ4 DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 Chemical Structure
  101. GC14298 DMH-1

    BMP Inhibitor II, DorsoMorphin Homolog 1, VU036482

     Selective BMP ALK2 receptor DMH-1 Chemical Structure

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