GLPBio

TP-004

Catalog No.: GC60368Purity:>98.00%
COASDSData Sheet
TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM.

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TP-004
Cas No.: 1454299-21-8
10mM (in 1mL DMSO)In Stock
$356.00
1
1mgIn Stock
$130.00
1
5mgIn Stock
$324.00
1
10mgIn Stock
$522.00
1
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM[1].

[1]. Cheruvallath, Z., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1. Bioorganic & Medicinal Chemistry Letters, 26(12), 2774-2778.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1454299-21-8
SMILES
O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1
Molecular Formula
C17H16F3N5O
Molecular Weight
363.34
Solubility
DMSO: 250 mg/mL (688.06 mM)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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