GLPBio

Tryptophan Hydroxylase

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Thrombin is a serine protease that in humans is encoded by the F2 gene. Thrombin is an intriguing coagulation protease demonstrating an array of effects on endothelial cells, vascular smooth muscle cells (VSMC), monocytes, and platelets, all of which are involved in the pathophysiology of atherosclerosis. There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes into the atherosclerotic lesions, induction of diverse pro-inflammatory markers, and all of these are related to the progression of cardiovascular disease. Recent studies in transgenic mice models indicate that the deletion of the natural thrombin inhibitor heparin cofactor II promotes an accelerated atherogenic state. The combined evidence points to thrombin as a pivotal contributor to vascular pathophysiology.

Products Related to Tryptophan Hydroxylase(12)

  • GC10007 structure
    GC10007LX1606 Hippurate (Telotristat etiprate)
    CAS: 1137608-69-5
    Purity: >99.50%

    LX1606 Hippurate (Telotristat etiprate) is an oral, systemically available, small-molecule inhibitor of peripheral serotonin (5-HT) synthesis.

  • GC13293 structure
    GC13293LP533401 hcl
    CAS: 1040526-12-2
    Purity: >98.00%

    LP533401 hcl is a tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

  • GC14064 structure
    GC14064p-Chlorophenylalanine
    CAS: 7424-00-2
    Purity: >99.50%

    p-Chlorophenylalanine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin.

  • GC15998 structure
    GC15998LX-1031
    CAS: 945976-76-1
    Purity: >99.50%
  • GC16279 structure
    GC16279Telotristat
    CAS: 1033805-28-5
    Purity: >98%

    TPH inhibitor

  • GC37755 structure
    GC37755LX1606 (Telotristat ethyl)
    CAS: 1033805-22-9
    Purity: >99.00%

    LX1606 (Telotristat ethyl) (LX1032) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

  • GC44083 structure
    GC44083LP-533401
    CAS: 945976-43-2
    Purity: >98.00%

    LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that blocks the biosynthesis of gut-derived serotonin, completely inhibiting serotonin production in Tph1-expressing cells at a dose of 1 μM.

  • GC60516 structure
    GC605164-Ethynyl-L-phenylalanine hydrochloride
    CAS: 188640-63-3
    Purity: >98.00%

    4-Ethynyl-L-phenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM.

  • GC61463 structure
    GC61463p-Ethynylphenylalanine
    CAS: 278605-15-5
    Purity: >97.00%

    p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM.

  • GC62458 structure
    GC62458Rodatristat ethyl
    CAS: 1673571-51-1
    Purity: >98%

    Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency.

  • GC63842 structure
    GC63842Rodatristat
    CAS: 1673568-73-4
    Purity: >98%

    Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.

  • GC73721 structure
    GC73721TPT-004
    CAS: 3032648-15-7
    Purity: >99.00%

    TPT-004 is a TPH inhibitor.