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type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus] (Synonyms: H2N-Leu-Asn-Asp-Arg-Leu-Ala-Ser-Tyr-Leu-OH )

Catalog No.GP10050

type I hair keratin

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type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus] Chemical Structure

Size Price Stock Qty
1mg
$35.00
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5mg
$107.00
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10mg
$191.00
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25mg
$258.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

The human type I hair keratin subfamily comprises nine individual members, which can be subdivided into three groups. Group A (hHa1, hHa3-I, hHa3-II, hHa4) and B (hHa7, hHa8) each contains structurally related hair keratins, whereas group C members hHa2, hHa5, and hHa6 represent structurally rather unrelated hair keratins1.

Keratins are divided into type I (acidic) and type II (basic to neutral) members, which form the 10-nm intermediate filament cytoskeletal network of epithelial cells through obligatory association of equimolar amounts of type I and type II keratins2,3,4.

The various type I hair keratin antibodies proved to be highly specific in that they recognized only single protein bands when analyzed in Western blots of one dimensionally resolved human hair keratins. One exception concerned the hHa2 antibody, which besides the prominent hHa2 protein band also reacted with a slightly larger minor band1. . A LEF-1 consensus sequence is invariably located at a highly conserved position in the proximal promoter region of the members of the human type I hair keratin family but it is specifically lacking in the entire promoter of the hHa7 gene5.

References:
1. L. Langbein, M. A. Rogers et al. The Catalog of Human Hair Keratins. The journal of biological chemistry. 274: 19874-19884, 1999
2.Steinert, P. M., and Roop, D. R. (1988) Annu. Rev. Biochem. 57, 593-625.
3.Fuchs, E., and Weber, K. (1994) Annu. Rev. Biochem. 63, 345-382.
4.Mischke, D. (1998) in Intermediate Filaments: Subcellular Biochemistry (Herrmann, H., and Harris, J. R., eds) Vol. 31, pp. 71-95, Plenum Press, New York.
5.Rogers, M. A., Winter, H., Wolf, C., Jacobs, M., and Schweizer, J. (1998)J. Biol. Chem. 273, 26683-26691.

Chemical Properties

Cas No. SDF
Synonyms H2N-Leu-Asn-Asp-Arg-Leu-Ala-Ser-Tyr-Leu-OH
Canonical SMILES NC(CC(C)C)C(NC(CC(N)=O)C(NC(CC(O)=O)C(NC(CCCNC(N)=N)C(NC(CC(C)C)C(NC(C)C(NC(CO)C(NC(CC1=CC=C(O)C=C1)C(NC(CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula C47H77N13O15 M.Wt 1064.19
Solubility ≥106.4mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.9397 mL 4.6984 mL 9.3968 mL
5 mM 0.1879 mL 0.9397 mL 1.8794 mL
10 mM 0.094 mL 0.4698 mL 0.9397 mL
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Reviews

Review for type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus]

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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