GLPBio

UH15-38 TFA

Catalog No.: GC78942Purity:>99.50%
COASDSData Sheet
UH15-38 TFA is a potent RIPK3 inhibitor with an IC50 value of 20 nM.

Products are for research use only. Not for human use. We do not sell to patients.

UH15-38 TFA
1mgIn Stock
$135.00
1
5mgIn Stock
$333.00
1
10mgIn Stock
$540.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

UH15-38 TFA is a potent RIPK3 inhibitor with an IC50 value of 20 nM. UH15-38 TFA blocks IAV (influenza A virus)-activated necroptosis. UH15-38 TFA dampens IAV-induced lung injury [1].

In Vivo, UH15-38 (30 mg/kg; i.p.; daily for 4 days) TFA inhibits IAV (Influenza A virus)-induced lung injury in mice[1].

In Vitro, UH15-38 (0-1000 nM; 12 h) TFA decreases the expression of pMLKL induced by TCZ in a dose-dependent manner[1]. UH15-38 (0-1000 nM) TFA protects type I alveolar epithelial cells from canonical TNF-induced necroptosis and prevents IAV-induced necroptosis[1].

References:
[1]. Gautam A, et al. Necroptosis blockade prevents lung injury in severe influenza. Nature. 2024 Apr;628(8009):835-843.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C28H28F3N5O4
Molecular Weight
555.55
Storage
Store at -20°C, sealed storage, away from moisture and light
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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