ULK

ULK1, a serine/threonine protein kinase, is an enzyme that in humans is encoded by the ULK1 gene. ULK1 is essential for the initial stages of autophagy. ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.

ULK2 is essential for astrocyte transformation and tumor growth. ULK2 also inhibits the growth of glioma cells, which requires autophagy induction as kinase mutant of ULK2 fails to induce autophagy and inhibit growth. ULK2 and its homologue ULK1 are only down-regulated in all grades of glioma. Thus these results altogether suggest that inhibition of autophagy by ULK1/2 down-regulation is essential for glioma development.

Products Related to ULK(13)

GC14086 MRT68921
CAS: 1190379-70-4
Purity: >98%
MRT68921 is a potent dual inhibitor of ULK1 and ULK2 with IC 50 values of 2.9nM and 1.1nM, respectively.
GC15654 SBI-0206965
CAS: 1884220-36-3
Purity: >99.00%
SBI-0206965 , the pyrimidine derivative , is a highly selective kinase ULK1 inhibitor with an IC 50 value of 108nM.
GC17136 MRT67307
CAS: 1190378-57-4
Purity: >98.50%
A kinase inhibitor
GC19236 LYN-1604
CAS: 2088939-99-3
Purity: >98%
LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) agonist with an EC50 of 18.94 nM.
GC34315 ULK-101
CAS: 2443816-45-1
Purity: >99.50%
ULK-101 is a selective ULK1 inhibitor (IC₅₀=1.6nM) that inhibits ULK2 activity (IC₅₀=30nM).
GC36517 LYN-1604 hydrochloride
CAS: 2216753-86-3
Purity: >98%
LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).
GC36654 MRT68921 dihydrochloride
CAS: 2080306-21-2
Purity: >99.50%
MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.
GC60891 GW406108X
CAS: 1644443-92-4
Purity: >98.00%
GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.
GC62146 XST-14
CAS: 2607143-50-8
Purity: >99.50%
XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects.
GC73892 DCC-3116
CAS: 2543673-19-2
Purity: >99.00%
DCC-3116 is an orally active ULK1/2 inhibitor.
GC78994 SBP-1750
CAS: 1884219-70-8
Purity: >98.00%
SBP-1750 is an orally active ULK inhibitor and an ATG13 degrader.
GC81304 GW296115
CAS: 118458-58-5
Purity: >98.50%
GW296115 is a multi-target inhibitor with the following IC 50 values against its targets: 8.4 nM for BRSK2, 21 nM for BRSK1, 1.8 μM for PDGFRβ, 5.5 nM for STK17B/DRAK2, 28 nM for DRAK1, 20 nM for PHKG1, and 89 nM for DCAMKL3.
GC81673 UE01
CAS: 486440-74-8
Purity: >98%
UE01 is an orally active, selective small-molecule modulator targeting both ULK1/ERK1/2.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC14086	MRT68921	1190379-70-4	>98%
GC14086	MRT68921 is a potent dual inhibitor of ULK1 and ULK2 with IC 50 values of 2.9nM and 1.1nM, respectively.
GC15654	SBI-0206965	1884220-36-3	>99.00%
GC15654	SBI-0206965 , the pyrimidine derivative , is a highly selective kinase ULK1 inhibitor with an IC 50 value of 108nM.
GC17136	MRT67307	1190378-57-4	>98.50%
GC17136	A kinase inhibitor
GC19236	LYN-1604	2088939-99-3	>98%
GC19236	LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) agonist with an EC50 of 18.94 nM.
GC34315	ULK-101	2443816-45-1	>99.50%
GC34315	ULK-101 is a selective ULK1 inhibitor (IC₅₀=1.6nM) that inhibits ULK2 activity (IC₅₀=30nM).
GC36517	LYN-1604 hydrochloride	2216753-86-3	>98%
GC36517	LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).
GC36654	MRT68921 dihydrochloride	2080306-21-2	>99.50%
GC36654	MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.
GC60891	GW406108X	1644443-92-4	>98.00%
GC60891	GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.
GC62146	XST-14	2607143-50-8	>99.50%
GC62146	XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects.
GC73892	DCC-3116	2543673-19-2	>99.00%
GC73892	DCC-3116 is an orally active ULK1/2 inhibitor.
GC78994	SBP-1750	1884219-70-8	>98.00%
GC78994	SBP-1750 is an orally active ULK inhibitor and an ATG13 degrader.
GC81304	GW296115	118458-58-5	>98.50%
GC81304	GW296115 is a multi-target inhibitor with the following IC 50 values against its targets: 8.4 nM for BRSK2, 21 nM for BRSK1, 1.8 μM for PDGFRβ, 5.5 nM for STK17B/DRAK2, 28 nM for DRAK1, 20 nM for PHKG1, and 89 nM for DCAMKL3.
GC81673	UE01	486440-74-8	>98%
GC81673	UE01 is an orally active, selective small-molecule modulator targeting both ULK1/ERK1/2.