GLPBio

VU6019650

Catalog No.: GC70135Purity:>98.50%
COASDSData Sheet

VU6019650 is a potent and selective M5 mAChR positive allosteric modulator (IC50=36 nM) that can be used for research on alleviating opioid use disorder (OUD). VU6019650 has blood-brain barrier permeability and may regulate the mesolimbic dopamine reward circuit. VU6019650 can block the increase in firing rate of ventral tegmental area (VTA) dopamine neurons induced by Oxotremorine M iodide.

Products are for research use only. Not for human use. We do not sell to patients.

VU6019650
10mgIn Stock
$720.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Product Documents

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C18H22FN3O3S2
Molecular Weight
411.51
Solubility
DMSO : 8.33 mg/mL (20.24 mM; ultrasonic and warming and heat to 60°C)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

Reviews

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