VU6052254, a derivative of VU0467319, is a selective, potent, orally active and brain-penetrant muscarinic M1 acetylcholine receptor ( mAChR1 ) positive allosteric modulator with an EC 50 of 59 nM. VU6052254 has no activity on the M2-5 receptor ( EC 50 > 30 μM). VU6052254 can improve memory recognition ability and reverse the cognitive impairment induced by Scopolamine with minimum effective dose both of 1 mg/kg. VU6052254 can be used for the research of neurological disease, such as Alzheimer's disease [1].
References:
[1]. Engers JL, et al. Discovery of VU6052254: A Novel, Potent M1 Positive Allosteric Modulator. ACS Chem Neurosci. 2025 Dec 17;16(24):4741-4750.
References:
[1]. Engers JL, et al. Discovery of VU6052254: A Novel, Potent M1 Positive Allosteric Modulator. ACS Chem Neurosci. 2025 Dec 17;16(24):4741-4750.