GLPBio

WIN 66,306

Catalog No.: GC48371Purity:>95.00%
COASDSData Sheet
A peptide antagonist of NK1 and NK2 receptors

Products are for research use only. Not for human use. We do not sell to patients.

WIN 66,306
Cas No.: 151928-32-4
1mgIn Stock
$373.00
1
5mgIn Stock
$1,486.00
1
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Description

WIN 66,306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes.1 It binds to NK1 and NK2 receptors (Kis = 8 and 3.8 µM, respectively, for the human receptors) and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.

1.Barrow, C.J., Doleman, M.S., Bobko, M.A., et al.Structure determination, pharmacological evaluation, and structure-activity studies of a new cyclic peptide substance P antagonist containing the new amino acid 3-prenyl-β-hydroxytyrosine, isolated from Aspergillus flavipesJ. Med. Chem.37(3)356-363(1994)

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
151928-32-4
SMILES
O=C(N1[C@@](C(NCC(N[C@H](C(NCC(N[C@@](C(NCC(N2)=O)=O)([H])[C@@H](C3=CC(C/C=C(C)\C)=C(C=C3)O)O)=O)=O)C(C)C)=O)=O)([H])CCC1)[C@@H]2CC4=CNC5=CC=CC=C45
Molecular Formula
C41H52N8O9
Molecular Weight
800.9
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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