GLPBio

XL 188

Catalog No.: GC72934Purity:>98.00%
COASDSData Sheet
XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively.

Products are for research use only. Not for human use. We do not sell to patients.

XL 188
Cas No.: 2305045-76-3
10mM (in 1mL DMSO)In Stock
$135.00
1
1 mgIn Stock
$36.00
1
5 mgIn Stock
$85.00
1
10 mgIn Stock
$144.00
1
25 mgIn Stock
$306.00
1
50 mgIn Stock
$490.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    Nature
    641, 529–536 (2025)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer.

XL 188 (1-20 μM; 16 h; MCF7 cells) promotes USP7 dependent loss of HDM2 and increase of p53 and p21[1].

References:
[1]. Stolte B, et, al. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018 Aug 6;215(8):2137-2155.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2305045-76-3
Molecular Formula
C32H42N6O4
Molecular Weight
574.71
Solubility
DMSO : 100 mg/mL (174.00 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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