GLPBio

YL-365

Catalog No.: GC73706Purity:>98.00%
COASDSData Sheet

YL-365 is a potent GPR34 antagonist with an IC50 value of 17nM.

Products are for research use only. Not for human use. We do not sell to patients.

YL-365
Cas No.: 3077715-58-0
1mgIn Stock
$70.00
1
5mgIn Stock
$166.00
1
10mgIn Stock
$280.00
1
25mgIn Stock
$551.00
1
50mgIn Stock
$772.00
1
100mgIn Stock
$1,040.00
1
200mgIn Stock
$1,392.00
1
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    187(9):2288-2304 (2024)
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Description

YL-365 is a potent GPR34 antagonist with an IC50 value of 17nM [1]. YL-365 competitively binds to the region of the GPR34 orthosteric binding pocket and induces receptor conformational changes to exert an inhibitory effect [2]. YL-365 is widely used for targeting the ADAM8 gene to inhibit the progression of clear cell renal cell carcinoma[3].

In vivo, YL-365 treatment via intraperitoneal injection at a dose of 20mg/kg (twice a day) for 3 days substantially reduced mechanical allodynia in the mouse model of neuropathic pain with the L4 spinal nerve being cut off [2].

References:
[1] Chakraborty A, Kamat S S. Lysophosphatidylserine: A signaling lipid with implications in human diseases[J]. Chemical reviews, 2024, 124(9): 5470-5504.
[2] Xia A, Yong X, Zhang C, et al. Cryo-EM structures of human GPR34 enable the identification of selective antagonists[J]. Proceedings of the National Academy of Sciences, 2023, 120(39): e2308435120.
[3] Wu Y, Zhang Y, Sun K, et al. Prognostic significance of key immune cell functional alterations in clear cell renal cell carcinoma[J]. Translational Cancer Research, 2025, 14(10): 6364-6387.

Protocol

Animal experiment [1]:

Animal models

 C57BL/6J mice

Preparation Method

 Male C57BL/6J (6 weeks old) were maintained on a 12:12 light–dark cycle at a room temperature of 22±1℃.To produce the spinal nerve injury (SNI) in mice, the mice were anesthetized with isoflurane and the L4 spinal nerves were cut off. For sham operations, the L4 spinal nerve was exposed but not cut off. Mice were intraperitoneal injected with vehicle or YL-365 (20mg/kg; i.p.; twice a day) 5h after operation. The mechanical allodynia was assessed by the plantar aesthesiometer following 3-day administration of vehicle or YL-365.

Dosage form

 20mg/kg; twice a day for 3 days; i.p.

Applications

 YL-365 treatment substantially reduced mechanical allodynia in mice.

References:
[1] Xia A, Yong X, Zhang C, et al. Cryo-EM structures of human GPR34 enable the identification of selective antagonists[J]. Proceedings of the National Academy of Sciences, 2023, 120(39): e2308435120.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
3077715-58-0
Molecular Formula
C34H31ClN2O5
Molecular Weight
583.07
Solubility
DMSO : 200 mg/mL (343.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Storage
4°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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