GLPBio

ACTH (7-38) (human) (trifluoroacetate salt)

Catalog No.: GC92123Purity:>95.00%Synonyms: Adrenocorticotropic Hormone (7-38); α7-38-ACTH; CIP; Corticotropin Inhibitory Peptide
COASDSData Sheet
Adrenocorticotropic hormone (ACTH) (7-38) is a peptide fragment of ACTH and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor.

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ACTH (7-38) (human) (trifluoroacetate salt)
500 µgIn Stock
$59.00
1
1 mgIn Stock
$112.00
1
5 mgIn Stock
$441.00
1
10 mgIn Stock
$706.00
1
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Description

Adrenocorticotropic hormone (ACTH) (7-38) is a peptide fragment of ACTH and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor.1 It inhibits ACTH-induced corticosterone production in isolated rat adrenal cells when used at concentrations of 0.455 or 4.55 ?M. ACTH (7-38) also inhibits angiotensin-converting enzyme 1 (ACE1; IC50 = 750 nM for the dog enzyme).2 It inhibits basal cAMP secretion by isolated rat inner adrenocortical cells when used at a concentration of 1 ?M.3 ACTH (7-38) induces hypotension in normotensive dogs (ED50 = 0.109 nmol/kg).4

References:
[1]. Li, C.H., Chung, D., Yamashiro, D., et al.Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glandsProc. Natl. Acad. Sci. U.S.A.75(9)4306-4309(1978).
[2]. Verma, P.S., Miller, R.L., Taylor, R.E., et al.Inhibition of canine lung angiotensin converting enzyme by ACTH and structurally related peptidesBiochem. Biophys. Res. Commun.104(4)1484-1488(1982).
[3]. Mazzocchi, G., Rebuffat, P., Gottardo, L., et al.Vasoactive intestinal peptide stimulates rat adrenal glucocorticoid secretion, through an ACTH receptor-dependent activation of the adenylate cyclase signaling pathwayHorm. Metab. Res.30(5)241-243(1998).
[4]. Tenner, T.E., Jr., Yang, C.M., Chang, J.K., et al.Pharmacological comparison of bPTH-(1-34) and other hypotensive peptides in the dogPeptides1(4)285-288(1980).

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Synonyms
Adrenocorticotropic Hormone (7-38); α7-38-ACTH; CIP; Corticotropin Inhibitory Peptide
Chemical Name
31-L-serine-α7-38-corticotropin (swine), trifluoroacetate salt
SMILES
O=C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CC1=CN([H])C2=C1C=CC=C2)C(NCC(N[C@@H](CCCCN[H])C(N3CCC[C@H]3C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(N4CCC[C@H]4C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@H](CC5=CC=C(O[H])C=C5)C(N6CCC[C@H]6C(N[C@@H](CC(N[H])=O)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N7CCC[C@H]7C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CC(C)C)=O)=O)CC8=CC=CC=C8)=O)C)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](N[H])CC9=CC=CC=C9.O=C(O)C(F)(F)F
Molecular Formula
C167H257N47O46 ? XCF3COOH
Molecular Weight
3659.2
Solubility
DMSO: Soluble: ≥10 mg/ml,PBS (pH 7.2): Soluble: ≥10 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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