ADDA 5 hydrochloride

Name: ADDA 5 hydrochloride
Brand: GlpBio
SKU: GC32251
Availability: InStock

Catalog No.: GC32251Purity:>98.00%

ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.

Products are for research use only. Not for human use. We do not sell to patients.

Cas No.: 473268-46-1

10mM (in 1mL DMSO)In Stock

$92.00

5mgIn Stock

$83.00

10mgIn Stock

$142.00

25mgIn Stock

$313.00

Pack Size	Price	Availability	Quantity
10mM (in 1mL DMSO)	$92.00	In Stock	1
5mg	$83.00	In Stock	1
10mg	$142.00	In Stock	1
25mg	$313.00	In Stock	1

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Citations

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Nature
641, 529–536 (2025)
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Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
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387(6739) (2025)
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387(6734) (2025)
Cell Research
35, 97–116 (2025)
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33, 273–287 (2023)
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33, 546–561 (2023)
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Cell Research
31, 1291–1307 (2021)

Description

ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.

ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC50s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC50 of 8.17 μM[1].

ADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice[1].

[1]. Oliva CR, et al. Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells. J Biol Chem. 2016 Nov 11;291(46):24188-24199. Epub 2016 Sep 27.

Protocol

Animal experiment:

UTMZ cells are transplanted into mice at 6 weeks of age, and after 12 days the mice are treated intraperitoneally with ADDA 5 (8 mg/kg) or DMSO-saline as a control. Tumor volume is measured once each week, starting at day 28 when tumors become visible. At 43 days, animals reach the end point and are killed, and the final tumor volume of both groups is determined[1].

References:

Product Documents

Batch:Purity:>98.00%Appearance:A solid

COA SDS Data Sheet

Chemical Properties

CAS No.

473268-46-1

SMILES

OC(COCCC1(C2)CC3CC2CC(C3)C1)CN4CC5=C(C=CC=C5)CC4.[H]Cl

Molecular Formula

C₂₄H₃₆ClNO₂

Molecular Weight

406

Solubility

DMSO : 65 mg/mL (160.10 mM)

Storage

Store at -20°C

General tips

Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.

Shipping Condition

Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

Mass

Volume

Concentration

Molecular Weight

g/mol

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