Alendronate sodium hydrate
Catalog No.: GC10348Purity:>98.00%Synonyms: Adronat, Fosamax, G-704650, MK-217
Alendronate sodium hydrate is a nitrogen-containing bisphosphonate that strongly inhibits bone resorption, it is often used in research on the prevention and treatment of osteoporosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 121268-17-5
10mM (in 1mL Water)In Stock
$50.00
1
100mgIn Stock
$45.00
1
500mgIn Stock
$144.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL Water) | $50.00 | In Stock | 1 | |
| 100mg | $45.00 | In Stock | 1 | |
| 500mg | $144.00 | In Stock | 1 |
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Citations
2 publicationsPublications from researchers using this productDescription
Alendronate sodium hydrate is a nitrogen-containing bisphosphonate that strongly inhibits bone resorption, it is often used in research on the prevention and treatment of osteoporosis [1]. Alendronate sodium hydrate has a strong affinity for circulating calcium and minerals on the bone surface, and inhibits the enzyme activity in osteoclasts, thereby hindering the dissolution of bone tissue and the degradation of collagen [2].
Alendronate sodium hydrate (10-4mol/L) incubated for 48 hours significantly reduced the collagen synthesis of osteoblasts. Alendronate sodium hydrate at a concentration of 10-12-10-5mol/L has no effect on calcium deposition in normal human osteoblasts [3].
Alendronate sodium hydrate (25mg/kg) treatment twice each week for 8 weeks, exhibited a reversal of mouse liver fibrosis to a significant extent, and the expression of α-SMA positive cells in the hepatic fibrosis area was significantly reduced in CCl4 induced liver fibrosis mouse model [4]. Alendronate sodium hydrate (0.01 to 0.25mg/kg, s.c., 11 days) preserves alveolar bone resorption and has anti-inflammatory and antibacterial activities in experimental periodontitis [5]. Alendronate sodium hydrate pretreated mice (0.1mg/kg twice a week or once a week) combined with paclitaxel administration (10-50mg/kg/day twice a week or once a week) statistically significantly blocked the growth of PC3 ML tumors in bone marrow and soft tissue. And significantly improve survival time [6].
References:
[1] Bell NH, Johnson RH. Bisphosphonates in the treatment of osteoporosis. Endocrine. 1997 Apr;6:203-6.
[2] Iwamoto J, Miyata A, Sato Y, Takeda T, Matsumoto H. Five-year alendronate treatment outcome in older postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures. Therapeutics and Clinical Risk Management. 2009 Oct 12:773-9.
[3] Garcia-Moreno C, Serrano S, Nacher M, Farré M, Diez A, Marinoso ML, Carbonell J, Mellibovsky L, Nogués X, Ballester J, Aubía J. Effect of alendronate on cultured normal human osteoblasts. Bone. 1998 Mar 1;22(3):233-9.
[4] Bi WR, Jin CX, Xu GT, Yang CQ. Effect of alendronate sodium on the expression of mesenchymal-epithelial transition markers in mice with liver fibrosis. Experimental and Therapeutic Medicine. 2013 Jan;5(1):247-52.
[5] Menezes AM, Rocha FA, Chaves HV, Carvalho CB, Ribeiro RA, Brito GA. Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats. Journal of periodontology. 2005 Nov;76(11):1901-9.
[6] Stearns ME, Wang M. Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice. Invasion & Metastasis. 1996 Jan 1;16(3):116-31.
Protocol
| Cell experiment [1]: | |
Cell lines | Human bone cells |
Preparation Method | A stock solution of Alendronate sodium hydrate was prepared by dissolving at a concentration of 10mol/L in DMEM. Culture media were prepared at final concentrations of alendronate between 10-12 to 10-1mol/L, with 1:10 serial dilutions of the stock solutions. Medium with or without Alendronate sodium hydrate was then added and the cells incubated for 48 or 96h. |
Reaction Conditions | 10-12 to 10-1mol/L; 48 or 96h |
Applications | After 96 h of incubation, cell viability was significantly decreased at the Alendronate sodium hydrate concentration of 10-4mol/L. |
| Animal experiment [2]: | |
Animal models | Ovariectomized female Wistar rats |
Preparation Method | The animals were divided into four groups: ovariectomized (OVX group); ovariectomized and treated with 1mg/kg or 2mg/kg Alendronate sodium hydrate (ALN) salt diluted in saline solution (Group OVX + ALN1 and Group OVX + ALN2); and a sham operated group used as the control. |
Dosage form | 1 or 2mg/kg; s.c.; twice a week |
Applications | The rats began treatment immediately following ovariectomy and both doses of Alendronate sodium hydrate proved effectiveness in controlling mineral loss. |
References: | |
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
121268-17-5
Synonyms
Adronat, Fosamax, G-704650, MK-217
Chemical Name
sodium hydrogen(4-amino-1-hydroxy-1-phosphonobutyl)phosphonate trihydrate
SMILES
[O-]P(O[H])(C(O[H])(C([H])([H])C([H])([H])C([H])([H])N([H])[H])P(O[H])(O[H])=O)=O.[H]O[H].[H]O[H].[H]O[H].[Na+]
Molecular Formula
C4H18NNaO10P2
Molecular Weight
325.12
Solubility
≥ 5.57mg/mL in Water
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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