Cerebellin TFA is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin TFA stimulates norepinephrine release via the adenylate cyclase / PKA -dependent signaling pathway. Cerebellin TFA reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin TFA also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin TFA can be used in neurological research [1] [2] [3] [4].
In Vivo, Cerebellin (1-1000 nM; intrarenal adrenal perfusion; continuous administration during sample collection) TFA potently stimulates norepinephrine release from perfused rat adrenal glands via an adenylate cyclase/PKA-dependent pathway[1]. Cerebellin (0.5-1.5 nmol/100 g body weight; subcutaneous injection; single bolus) TFA acts as an insulin inhibitor in healthy female Wistar rats[2].
In Vitro, Cerebellin (1-100 nM; 10-30 min) TFA potently stimulates the production of norepinephrine and cyclic adenosine monophosphate in rat adrenal medullary tissues via an adenylate cyclase/PKA-dependent pathway[1]. Cerebellin (1-100 nM; 90 min) TFA inhibits glucose-stimulated insulin secretion from isolated rat islets[2]. Cerebellin (100 nM-1 μM; 1 hour) TFA inhibits glucose/Exendin-4 -stimulated insulin secretion in INS-1 cells[2]. Cerebellin (10 nM-1 μM; 5 min) TFA reduces Forskolin -induced cAMP accumulation in INS-1 cells in a concentration-dependent manner[2]. Cerebellin (100 nM) TFA irreversibly reduces the intracellular free calcium concentration in INS-1 cells[2].
References:
[1]. Albertin G, et al. Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. Neuropeptides. 2000;34(1):7-11.
[2]. Strowski MZ, et al. Insulinostatic activity of cerebellin--evidence from in vivo and in vitro studies in rats. Regul Pept. 2009;157(1-3):19-24.
[3]. Slemmon JR, et al. Cerebellin: a quantifiable marker for Purkinje cell maturation. Proc Natl Acad Sci U S A. 1985;82(20):7145-7148.
[4]. Mugnaini E, et al. The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain. Proc Natl Acad Sci U S A. 1987;84(23):8692-8696.
In Vivo, Cerebellin (1-1000 nM; intrarenal adrenal perfusion; continuous administration during sample collection) TFA potently stimulates norepinephrine release from perfused rat adrenal glands via an adenylate cyclase/PKA-dependent pathway[1]. Cerebellin (0.5-1.5 nmol/100 g body weight; subcutaneous injection; single bolus) TFA acts as an insulin inhibitor in healthy female Wistar rats[2].
In Vitro, Cerebellin (1-100 nM; 10-30 min) TFA potently stimulates the production of norepinephrine and cyclic adenosine monophosphate in rat adrenal medullary tissues via an adenylate cyclase/PKA-dependent pathway[1]. Cerebellin (1-100 nM; 90 min) TFA inhibits glucose-stimulated insulin secretion from isolated rat islets[2]. Cerebellin (100 nM-1 μM; 1 hour) TFA inhibits glucose/Exendin-4 -stimulated insulin secretion in INS-1 cells[2]. Cerebellin (10 nM-1 μM; 5 min) TFA reduces Forskolin -induced cAMP accumulation in INS-1 cells in a concentration-dependent manner[2]. Cerebellin (100 nM) TFA irreversibly reduces the intracellular free calcium concentration in INS-1 cells[2].
References:
[1]. Albertin G, et al. Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. Neuropeptides. 2000;34(1):7-11.
[2]. Strowski MZ, et al. Insulinostatic activity of cerebellin--evidence from in vivo and in vitro studies in rats. Regul Pept. 2009;157(1-3):19-24.
[3]. Slemmon JR, et al. Cerebellin: a quantifiable marker for Purkinje cell maturation. Proc Natl Acad Sci U S A. 1985;82(20):7145-7148.
[4]. Mugnaini E, et al. The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain. Proc Natl Acad Sci U S A. 1987;84(23):8692-8696.