GLPBio

DNQX (FG 9041)

Catalog No.: GC32755Purity:>98.00%Synonyms: 6,7Dinitroquinoxaline2,3dione, FG 9041
COASDSData Sheet
DNQX (FG 9041) (FG 9041) ، أحد مشتقات الكينوكسالين ، هو مضاد لمستقبلات الغلوتامات غير النمداوية والتنافسية الانتقائية (IC50s = 0.5 و 2 و 40 μ ؛ M لمستقبلات AMPA و kainate و NMDA ، على التوالي).

المنتجات مخصصة للاستخدام البحثي فقط، وليست للاستخدام البشري. نحن لا نبيع للمرضى.

DNQX (FG 9041)
Cas No.: 2379-57-9
10mM (in 1mL DMSO)In Stock
$33.00
1
10mgIn Stock
$30.00
1
25mgIn Stock
$44.00
1
50mgIn Stock
$70.00
1
100mgIn Stock
$100.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

المراجع (Citations)

لا تتوفر حاليًا مراجع لهذا المنتج. فيما يلي مجموعة مختارة من المنشورات التي تستشهد بمنتجات GlpBio.
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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الوصف (Description)

DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist, with IC50 values of 0.5, 2, and 40μM for AMPA, kainite, and NMDA receptors, respectively [1]. DNQX can inhibit the activation of JNK3 in the entire hippocampus of rats after ischemia, thereby regulating excitotoxicity and neuronal damage [2]. DNQX has been widely used to induce depolarization of neurons in the thalamic reticular nucleus (TRN) [3].

In vitro, DNQX treatment (10μM) for 72 hours significantly inhibited the death of rat retinal ganglion cells (RGCs) induced by glutamate [4]. Treatment with 100μM DNQX for 8 days significantly reduced cell viability in the dissociated cells of the rat embryonic neopallium[5].

In vivo, DNQX treatment via a single intraperitoneal injection at a dose of 10mg/kg for 30 minutes blocked the rapid tolerance to alcohol-induced motor impairment in mice [6]. DNQX treatment (1μg; 0.5μl) via injection bilaterally into the nucleus accumbens 15min prior to cocaine (20mg/kg; i.p.) attenuated the acquisition of place preference induced by cocaine in rats[7].

References:
[1] Honoré T, Davies S N, Drejer J, et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists[J]. Science, 1988, 241(4866): 701-703.
[2] Tian H, Zhang G, Li H, et al. Antioxidant NAC and AMPA/KA receptor antagonist DNQX inhibited JNK3 activation following global ischemia in rat hippocampus[J]. Neuroscience research, 2003, 46(2): 191-197.
[3] Lee S H, Govindaiah G, Cox C L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons[J]. Journal of neurophysiology, 2010, 103(4): 1728-1734.
[4] Aihara M, Chen Y N, Uchida S, et al. Hyperbaric pressure and increased susceptibility to glutamate toxicity in retinal ganglion cells in vitro[J]. Molecular vision, 2014, 20: 606.
[5] Drian M J, Bardoul M, König N. Blockade of AMPA/kainate receptors can either decrease or increase the survival of cultured neocortical cells depending on the stage of maturation[J]. Neurochemistry international, 2001, 38(6): 509-517.
[6] Rial D, Takahashi R N, Morato G S. Aniracetam and DNQX affect the acquisition of rapid tolerance to ethanol in mice[J]. Pharmacology Biochemistry and Behavior, 2009, 92(1): 32-38.
[7] Kaddis F G, Uretsky N J, Wallace L J. DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference[J]. Brain research, 1995, 697(1-2): 76-82.

البروتوكول (Protocol)

Cell experiment [1]:

Cell lines

Rat embryonic neopallium cells

Preparation Method

Rat embryonic neopallium cells were grown in culture medium consisted of minimal Eagle's medium (MEM) supplemented with 6g/l glucose and 5% Nu-serum in 5% CO2 at 37°C. Cells (3×103 cells/ml) were seeded in 96-well plates and allowed to adhere in a 5% CO2 incubator at 37°C overnight, and were treated with different concentrations of DNQX (0, 12, 25, 50, 75 and 100μM) for 8 days. The cell viability was evaluated.

Reaction Conditions

0, 12, 25, 50, 75 and 100μM; 8 days

Applications

DNQX treatment significantly reduced the cell viability of rat embryonic neopallium cells in a dose-dependent manner.
Animal experiment [2]:

Animal models

Male Sprague-Dawley rats

Preparation Method

Male Sprague-Dawley rats (250-350g) were housed in cages and maintained in air-conditioned animal quarters with a 12h light-dark cycle and free access to autoclaved tap water and a standard chow diet. The apparatus consisted of a large white and a large black chamber separated by a smaller neutral gray compartment. To initiate the experiment, rats were placed in the smaller chamber and allowed free access to both of the larger ones for 15min. All rats preferred the black chamber. Rats were then trained over an 8-day period, receiving cocaine before being confined to the white compartment on the odd-numbered training days and saline before being confined to the black compartment on the even-numbered training days. On the test day, the day after the final training session, rats were placed in the gray compartment and allowed free access to all compartments, and the time spent in each compartment was determined for 15min. Place preference data are expressed as the difference in minutes between time spent in the drug paired (conditioned stimulus) compartment, which was least preferred initially, and the time spent in the saline paired compartment. After the preconditioning baseline was determined, DNQX (1μg; 0.5μl) or saline was injected bilaterally into the nucleus accumbens 15min prior to cocaine (20mg/kg; i.p.).

Dosage form

1μg for once; nucleus accumbens injection

Applications

DNQX treatment attenuated the acquisition of place preference induced by cocaine in rats.

References:
[1] Drian M J, Bardoul M, König N. Blockade of AMPA/kainate receptors can either decrease or increase the survival of cultured neocortical cells depending on the stage of maturation[J]. Neurochemistry international, 2001, 38(6): 509-517.
[2] Kaddis F G, Uretsky N J, Wallace L J. DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference[J]. Brain research, 1995, 697(1-2): 76-82.

وثائق المنتج (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

الخصائص الكيميائية (Chemical Properties)

رقم CAS
2379-57-9
المرادفات
6,7Dinitroquinoxaline2,3dione, FG 9041
SMILES
O=C1C(NC2=CC([N+]([O-])=O)=C([N+]([O-])=O)C=C2N1)=O
الصيغة الجزيئية
C8H4N4O6
الوزن الجزيئي
252.14
الذوبانية
DMSO : ≥ 35 mg/mL (138.81 mM)
التخزين
Store at -20°C
إرشادات عامة
اختر مذيبًا مناسبًا وفقًا لبيانات ذوبانية المنتج. بعد التحضير، قسّم المحلول المخزون إلى أجزاء لتجنب دورات التجميد والذوبان المتكررة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
شروط الشحن
تُشحن عينات التقييم مع عبوات تبريد. وتُشحن الأحجام الأخرى المتاحة في درجة حرارة الغرفة، أو مع عبوات تبريد عند الطلب.

الحاسبات (Calculators)المولارية / التخفيف / الوزن الجزيئي / تحويل الوحدات / تركيبة داخل الجسم الحي / الذوبانية

g/mol

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